13 Result(s)

Article

Characterization of raloxifene as a potential pharmacological agent against SARS-CoV-2 and its variants

The new coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic, which so far has caused over 6 million deaths in 2 years, despite new vaccines and antiviral medications. Drug repurposing, an ap...

Daniela Iaconis, Licia Bordi, Giulia Matusali, Carmine Talarico… in Cell Death & Disease (2022)

Article

B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation

Combined antiretroviral therapy (cART) for HIV-1 dramatically slows disease progression among HIV⁺ individuals. Currently, lymphoma represents the main cause of death among HIV-1-infected patients. Detection of p...

Cinzia Giagulli, Francesca Caccuri, Simone Zorzan, Antonella Bugatti… in Cancer Gene Therapy (2021)

Article

A persistently replicating SARS-CoV-2 variant derived from an asymptomatic individual

Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favou...

Francesca Caccuri, Alberto Zani, Serena Messali… in Journal of Translational Medicine (2020)

Article

Heparin and heparan sulfate proteoglycans promote HIV-1 p17 matrix protein oligomerization: computational, biochemical and biological implications

p17 matrix protein released by HIV+ cells interacts with leukocytes heparan sulfate proteoglycans (HSPGs), CXCR1 and CXCR2 exerting different cytokine-like activities that contribute to AIDS pathogenesis. Sinc...

Antonella Bugatti, Giulia Paiardi, Chiara Urbinati, Paola Chiodelli… in Scientific Reports (2019)

Article

Human Herpesvirus 6A and 6B inhibit in vitro angiogenesis by induction of Human Leukocyte Antigen G

We have previously reported that human herpesvirus 6 (HHV-6) infection of endothelial cells (ECs) induces the loss of angiogenic properties, through the expression of HHV-6 U94, possibly associated to the rele...

Roberta Rizzo, Maria D’Accolti, Daria Bortolotti, Francesca Caccuri… in Scientific Reports (2018)

Article

Myroides odoratimimus urinary tract infection in an immunocompromised patient: an emerging multidrug-resistant micro-organism

Myroides spp. are common environmental organisms and they can be isolated predominantly in water, soil, food and in sewage treatment plants. In the last two decades, an increasing number of infections such as uri...

Giovanni Lorenzin, Giorgio Piccinelli… in Antimicrobial Resistance & Infection Contr… (2018)

Article

HIV-1 matrix protein p17 and its variants promote human triple negative breast cancer cell aggressiveness

The introduction of cART has changed the morbidity and mortality patterns affecting HIV-infected (HIV⁺) individuals. The risk of breast cancer in HIV⁺ patients has now approached the general population risk. Howe...

Francesca Caccuri, Francesca Giordano, Ines Barone… in Infectious Agents and Cancer (2017)

Article

HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders

Human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorder (HAND) remains an important neurological manifestation that adversely affects a patient’s quality of life. HIV-1 matrix protein p1...

Yasmin Zeinolabediny, Francesca Caccuri, Laura Colombo… in Scientific Reports (2017)

Article

A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17

Recent data highlight the presence, in HIV-1-seropositive patients with lymphoma, of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagenesis. We investigated the m...

Cinzia Giagulli, Pasqualina D’Ursi, Wangxiao He, Simone Zorzan… in Scientific Reports (2017)

Article

Cellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17

The human immune deficiency virus type 1 (HIV-1) matrix protein p17 (p17), although devoid of a signal sequence, is released by infected cells and detected in blood and in different organs and tissues even in ...

Francesca Caccuri, Maria Luisa Iaria, Federica Campilongo… in Scientific Reports (2016)

Article

Correction: Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

Nat. Med.; doi:10.1038/nm.4105; corrected online 16 June 2016 In the version of this article initially published online, an affiliation for Luca Schifanella was omitted and there was an error in the descriptio...

Monica Vaccari, Shari N Gordon, Slim Fourati, Luca Schifanella… in Nature Medicine (2016)

Article

Synthetic HIV-1 matrix protein p17-based AT20-KLH therapeutic immunization in HIV-1-infected patients receiving antiretroviral treatment: A phase I safety and immunogenicity study

Arnaldo Caruso, Marialuisa Iaria, Francesca Caccuri… in BMC Infectious Diseases (2014)