13 Result(s)

Article

A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer

The Hendra and Nipah viruses (HNVs) are highly pathogenic pathogens without approved interventions for human use. In addition, the interaction pattern between the attachment (G) and fusion (F) glycoproteins re...

Pengfei Fan, Mengmeng Sun, **nghai Zhang, Huajun Zhang, Yujiao Liu… in Nature Communications (2024)

Article

Potent human neutralizing antibodies against Nipah virus derived from two ancestral antibody heavy chains

Nipah virus (NiV) is a World Health Organization priority pathogen and there are currently no approved drugs for clinical immunotherapy. Through the use of a naïve human phage-displayed Fab library, two neutra...

Li Chen, Mengmeng Sun, Huajun Zhang, **nghai Zhang, Yanfeng Yao… in Nature Communications (2024)

Article

Epigenetic addition of m⁵C to HBV transcripts promotes viral replication and evasion of innate antiviral responses

Eukaryotic five-methylcytosine (m⁵C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown. In this study, functional m⁵C sites ...

Shuang Ding, Haibin Liu, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu… in Cell Death & Disease (2024)

Article

A potent, broadly protective vaccine against SARS-CoV-2 variants of concern

Since the first outbreak in December 2019, SARS-CoV-2 has been constantly evolving and five variants have been classified as Variant of Concern (VOC) by the World Health Organization (WHO). These VOCs were fou...

Ziyan Wang, Jiao An, Kunpeng Liu, Pin Yu, **n Fang, Jiadai Li, Hua Zhu… in npj Vaccines (2022)

Article

Ozone Gas Inhibits SARS-CoV-2 Transmission and Provides Possible Control Measures

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of deaths currently. Mounting effective responses to the pandemic have become top priorities for governments around th...

Junji Cao, Yecheng Zhang, Quanjiao Chen, Maosheng Yao… in Aerosol Science and Engineering (2021)

Article

Ozone Water Is an Effective Disinfectant for SARS-CoV-2

**ao Hu, Zhen Chen, Zhengyuan Su, Fei Deng, **nwen Chen, Qi Yang… in Virologica Sinica (2021)

Article

Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated multiple variants resistant to therapeutic antibodies. In this study, 12 high-affinity antibodies were generated from convalescent ...

Yuanyuan Qu, Xueyan Zhang, Meiyu Wang, Lina Sun, Yongzhong Jiang… in Virologica Sinica (2021)

Article

Temporal antibody responses to SARS-CoV-2 in patients of coronavirus disease 2019

Min Huang, Qing-Bin Lu, Han Zhao, Yulan Zhang, Zhiwei Sui, Liqun Fang… in Cell Discovery (2020)

Article

Author Correction: Characterization of a filovirus (Měnglà virus) from Rousettus bats in China

In the version of this Letter originally published, in the ‘Phylogenetic analysis’ section of the Methods, the authors mistakenly stated that the GenBank accession number for the Ravn virus genome sequence was...

**ng-Lou Yang, Chee Wah Tan, Danielle E. Anderson, Ren-Di Jiang… in Nature Microbiology (2019)

Article

Mutations in the C-terminus of HBoV NS1 affect the function of NP1

Human bocavirus 1 (HBoV1) is an autonomous parvovirus in the Bocaparvovirus genus. The multifunctional nuclear protein NP1 is involved in viral replication. In the present study, we found that the mutations in th...

Junmei Zhang, Yan Bai, Bing Zhu, Sujuan Hao, Zhen Chen, Hanzhong Wang… in Scientific Reports (2017)

Article

Identification of an RNase that preferentially cleaves A/G nucleotides

Ribonucleases play an important role in the RNA metabolism which is critical for the localization, stability and function of mature RNA transcripts. More and more ribonucleases were discovered in recent years ...

Jumin **e, Zhen Chen, Xueyan Zhang, Honghe Chen, Wuxiang Guan in Scientific Reports (2017)

Article

Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spreads rapidly and has a high case-mortality rate. The nucleocapsid protein (NP) of SARS-CoV may be critical for pathogenicity. This study s...

Qin Wang, Chuan Li, Quanfu Zhang, Tao Wang, Jiandong Li, Wuxiang Guan… in Virology Journal (2010)