7 Result(s)
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Wouter den Hollander
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Article
Open AccessWhat do we not know (yet) about recovery colleges? A study protocol on their (cost-)effectiveness, mechanisms of action, fidelity and positioning
Recovery Colleges (RCs) have spread across the globe as a new way of supporting people with mental vulnerabilities in their recovery journey. RCs focus on ‘learning’ rather than ‘curing’ and in that line facil...
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Article
Open AccessThe human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment
Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechani...
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Article
Open AccessCharacterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such a...
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Article
Open AccessGenome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulati...
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Article
Experimental observation of a polarization vortex at an optical bound state in the continuum
Optical bound states in the continuum (BICs) are states supported by a photonic structure that are compatible with free-space radiation, yet become perfectly bound for one specific in-plane momentum and wavele...
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Protocol
Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI)
The occurrence of drug-induced liver injury (DILI) after drug approval has often led to withdrawal from the market. Especially idiosyncratic DILI forms a major problem for pharmaceutical companies. Due to its ...
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Article
Open AccessThe transcriptional landscape of age in human peripheral blood
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression met...
