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Thymic epithelial tumour progression in an SV40T transgenic mouse model
There have been several reports that thymoma in human is a progressive disease, and that thymoma and thymic carcinoma form a continuum. We established a stable line of SV40T transgenic mice, which consistentl...
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Identification of radiation-specific responses from gene expression profile
The responses to ionizing radiation (IR) in tumors are dependent on cellular context. We investigated radiation-related expression patterns in Jurkat T cells with nonsense mutation in p53 using cDNA microarray...
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Adenovirus-TRAIL can overcome TRAIL resistance and induce a bystander effect
TRAIL is a cytokine with a unique ability to induce apoptosis selectively in many transformed cell lines. The instability of TRAIL and the resistance of some cancer cells to TRAIL present the main obstacles fo...
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Open AccessObesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer
To evaluate the relationship of genetic polymorphisms of ERCC2 and ERCC4 genes, both involved in nucleotide excision repair (NER), and the risk of breast cancer, a hospital-based case-control study was conduct...
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Open AccessCaveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing
Lipid rafts provide a platform for regulating cellular functions and participate in the pathogenesis of several diseases. However, the role of caveolin-1 in this process has not been elucidated definitely in n...
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Identification of origin of unknown derivative chromosomes by array-based comparative genomic hybridization using pre- and postnatal clinical samples
Microarray-based comparative genomic hybridization (array CGH) is a high-resolution and comprehensive method for detecting both genome-wide and chromosome-specific copy-number imbalance. We have developed an a...
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Open AccessLocal exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain
Even though there is no direct evidence to prove the cellular and molecular changes induced by radiofrequency (RF) radiation itself, we cannot completely exclude the possibility of any biological effect of mob...
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Open AccessErratum: Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain
Correction to: Experimental & Molecular Medicine (2008) 40, 294–303; doi:10.3858/emm.2008.40.3.294 The authors would like to amend the name of Tae-Hyoung Kim1 Tae-Hyung Kim1 The authors apologize for any incon...
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Open AccessA highly annotated whole-genome sequence of a Korean individual
The genome of an anonymous Korean male has been sequenced using a broad spread of genomic techniques. This combinatorial approach allows for detailed characterization of sequence and structural variation. The ...
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Open AccessComprehensive analysis of microRNA-mRNA co-expression in circadian rhythm
To investigate the potential role of microRNA (miRNA) in the regulation of circadian rhythm, we performed microarray-based expression profiling study of both miRNA and mRNA in mouse liver for 48 h at 4-hour in...
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Open AccessChemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-α mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE of TNF-α mRNA using RNA electropho...
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Open AccessLIN28B confers radio-resistance through the posttranscriptional control of KRAS
To screen the differentially expressed microRNAs related to radio-resistance, we compared the microRNA profiles of lung cancer cells with different responses to ionizing radiation (IR). Of 328 microRNAs in mic...
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Open AccessmiR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1
The activation of nuclear factor-kappa B1 (NFκB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for microRNAs (miRNAs...
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Open AccessTime-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines
Radiation is the most useful treatment modality for cancer patients. It initiates a series of signal cascades such as DNA damage response (DDR) signaling for repairing damaged DNA, arresting the cell cycle, an...
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Genome-Wide Analysis of THz-Bio Interaction
We now can predict the biological effects of electromagnetic field (EMF) exposure owing to advances in genomic technologies. Kee** pace with the development of available radiation sources, studies on biologi...
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Open AccessA genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
Although approximately 25 common genetic susceptibility loci have been identified to be independently associated with breast cancer risk through genome-wide association studies (GWAS), the genetic risk variant...
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Open AccessMultiphasic analysis of whole exome sequencing data identifies a novel mutation of ACTG1 in a nonsyndromic hearing loss family
The genetic heterogeneity of sensorineural hearing loss is a major hurdle to the efficient discovery of disease-causing genes. We designed a multiphasic analysis of copy number variation (CNV), linkage, and si...
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Open AccessHigh-power femtosecond-terahertz pulse induces a wound response in mouse skin
Terahertz (THz) technology has emerged for biomedical applications such as scanning, molecular spectroscopy and medical imaging. Although a thorough assessment to predict potential concerns has to precede befo...
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A novel mutation of TMPRSS3 related to milder auditory phenotype in Korean postlingual deafness: a possible future implication for a personalized auditory rehabilitation
Appropriate customized auditory rehabilitation for hearing impaired subjects requires prediction of residual hearing and progression of hearing loss. Mutations in TMPRSS3 encoding a transmembrane serine protease ...
