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Article
Repeated Exposure of Vancomycin to Vancomycin-Susceptible Staphylococcus aureus (VSSA) Parent Emerged VISA and VRSA Strains with Enhanced Virulence Potentials
The emergence of resistance against the last-resort antibiotic vancomycin in staphylococcal infections is a serious concern for human health. Although various drug-resistant pathogens of diverse genetic backgr...
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Article
Open AccessIntracellular and in vivo activities of oxazolidinone drugs against Mycobacterium avium complex infection
The prevalence of Mycobacterium avium complex-pulmonary disease (MAC-PD) has become a growing concern worldwide, and current treatments involving macrolides (clarithromycin [CLR] or azithromycin), ethambutol, and...
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Article
Construction of high-density transposon mutant library of Staphylococcus aureus using bacteriophage ϕ11
Transposon mutant libraries are an important resource to study bacterial metabolism and pathogenesis. The fitness analysis of mutants in the libraries under various growth conditions provides important clues t...
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Article
Raloxifene as a treatment option for viral infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused corona virus disease 2019 (COVID-19) pandemic and led to mass casualty. Even though much effort has been put into development of vaccine ...
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Article
A pursuit of Staphylococcus aureus continues: a role of persister cells
Staphylococcus aureus is a pathogen that causes critical diseases, such as pneumonia, endocarditis, and bacteremia, upon gaining access to the bloodstream of the host. Because host innate immunity alone cannot fi...
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Article
Open AccessIndependent Multi-states of Photo-responsive Polymer/Quantum Dot Nanocomposite Induced via Different Wavelengths of Light
Stimuli-responsive systems are attractive since their properties can be controlled by external stimuli and/or surrounding environment. Recently, more than one stimulus is utilized in order to enhance the perfo...
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Article
FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein
The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria1. For decades, it was thought that only class A penicillin-binding proteins (PBPs) and related enzymes effected peptidoglyca...
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Article
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic
Identifying targets of antibacterial compounds remains a challenging step in the development of antibiotics. We have developed a two-pronged functional genomics approach to predict mechanism of action that use...
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Article
Open AccessNovel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis
Recent data indicate that the metabolism of Mycobacterium tuberculosis (Mtb) inside its host cell is heavily dependent on cholesterol and fatty acids. Mtb exhibits a unique capacity to co-metabolize different car...
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Article
A synthetic lethal approach for compound and target identification in Staphylococcus aureus
A series of synthetic lethal strategies identifies a small-molecule inhibitor of Staphylococcus aureus DltB, links teichoic acid D-alanylation to virulence and identifies synergistic antibiotic drug combinations.
