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Article
Selection of climate variables in ant species distribution models: case study in South Korea
The selection of explanatory variables is important in modeling prediction of changes in species distribution in response to climate change. In this study, we evaluated the importance of variable selection in ...
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Article
Open AccessDiscovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the leading cause of chronic liver disease worldwide. Metabolic Dysfunction-Associated Steatohepatitis (MASH), an advanced form of ...
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Article
Open AccessHost-specific growth responses of Larix kaempferi and Quercus acutissima to Asian gypsy moth defoliation in central Korea
As the risk of gypsy moth outbreaks that have detrimental effects on forest ecosystem in the Northern Hemisphere increase due to climate change, a quantitative evaluation of the impact of gypsy moth defoliatio...
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Article
Open AccessLRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus
LRRC6 is an assembly factor for dynein arms in the cytoplasm of motile ciliated cells, and when mutated, dynein arm components remained in the cytoplasm. Here, we demonstrate the role of LRRC6 in the active nu...
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Article
Open AccessEfficacy and safety of prone position in COVID-19 patients with respiratory failure: a systematic review and meta-analysis
Prone position has already been demonstrated to improve survival in non-COVID acute respiratory distress syndrome and has been widely performed in COVID-19 patients with respiratory failure, both in non-intuba...
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Article
Open AccessEarly intubation and clinical outcomes in patients with severe COVID-19: a systematic review and meta-analysis
Evidence regarding the timing of the application of mechanical ventilation among patients with severe coronavirus disease (COVID-19) is insufficient. This systematic review and meta-analysis aimed to evaluate ...
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Article
Open AccessPyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
Obesity is now recognized as a disease. This study revealed a novel role for pyruvate dehydrogenase kinase (PDK) in diet-induced hypertrophic obesity. Mice with global or adipose tissue-specific PDK2 deficienc...
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Article
Open AccessProto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity
Zbtb7c is a proto-oncoprotein that controls the cell cycle and glucose, glutamate, and lipid metabolism. Zbtb7c expression is increased in the liver and white adipose tissues of aging or high-fat diet-fed mice...
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Article
Open AccessComparison of the clinical characteristics and mortality of adults infected with human coronaviruses 229E and OC43
The purpose of the study was to compare clinical characteristics and mortality among adults infected with human coronaviruses (HCoV) 229E and OC43. We conducted a retrospective cohort study of adults (≥ 18 yea...
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Article
Open AccessSelection and identification of a novel bone-targeting peptide for biomedical imaging of bone
The global burden of bone-related diseases is increasing in the aging society; thus, improved bone targeted imaging for their early identification and treatment are needed. In this study, we screened novel pep...
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Article
Open AccessPLCE1 regulates the migration, proliferation, and differentiation of podocytes
PLCE1 encodes phospholipase C epsilon, and its mutations cause recessive nephrotic syndrome. However, the mechanisms by which PLCE1 mutations result in defects associated with glomerular function are not clear. T...
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Article
A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo
Hair loss due to medical conditions, such as alopecia, male pattern baldness, and cancer chemotherapy treatment, has been a common problem for many individuals. Cyclosporin A (CsA), a fungal metabolite, has be...
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Article
Open AccessLung Cancer development and mortality in interstitial lung disease with and without connective tissue diseases: a five-year Nationwide population-based study
Connective tissue disease associated with interstitial lung disease (CTD-ILD) and interstitial lung disease (ILD) alone have same pathological and imaging backgrounds. However, the differences between lung can...
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Article
Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population
Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study...
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Article
Open AccessRisk factors for interstitial lung disease: a 9-year Nationwide population-based study
Understanding the risk factors that are associated with the development of interstitial lung disease might have an important role in understanding the pathogenetic mechanism of interstitial lung disease as wel...
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Article
Open AccessRisk of mortality associated with respiratory syncytial virus and influenza infection in adults
Respiratory syncytial virus (RSV) infection constitutes a substantial disease burden in the general population. However, the risk of death for RSV infection has been rarely evaluated with confounders or comorb...
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Article
Open AccessBioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors
Growth factors have great therapeutic potential for various disease therapy and tissue engineering applications. However, their clinical efficacy is hampered by low bioavailability, rapid degradation in vivo and ...
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Article
Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly
Martin Zenker, Corinne Antignac, Friedhelm Hildebrandt and colleagues report that mutations in OSGEP, TP53RK, TPRKB and LAGE3, genes encoding KEOPS-complex subunits, cause Galloway–Mowat syndrome, a recessive dis...
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Article
Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome
Friedhelm Hildebrandt and colleagues identify mutations in NUP93, NUP205 or XPO5 in patients with steroid-resistant nephrotic syndrome. They show that NUP93 and XPO5 interact with SMAD4 and that NUP93 mutations i...
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Article
A novel alginate quantification method using high-performance liquid chromatography (HPLC) for pretreatment of Saccharina japonica
A new analysis method for alginate quantification in the brown alga, Saccharina japonica, was developed and evaluated. In this method, (1) alginate was treated with Na2CO3; (2) the alginate-derived compound in th...
