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  1. Article

    Open Access

    Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency

    A molecular and functional link between neurotrophin signaling and cerebellar foliation is lacking. Here we show that constitutive knockout of two homologous genes encoding the RNA binding protein RBM4 results...

    Yu-Young Tsai, Chiu-Lun Shen, Dhananjaya D, Ching-Yen Tsai… in Communications Biology (2023)

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  2. Article

    Open Access

    Y14 governs p53 expression and modulates DNA damage sensitivity

    Y14 is a core component of the exon junction complex (EJC), while it also exerts cellular functions independent of the EJC. Depletion of Y14 causes G2/M arrest, DNA damage and apoptosis. Here we show that knoc...

    Chia-Chen Lu, Chi-Chieh Lee, Ching-Tzu Tseng, Woan-Yuh Tarn in Scientific Reports (2017)

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  3. Article

    Alternative Splicing in Acad8 Resulting a Mitochondrial Defect and Progressive Hepatic Steatosis in Mice

    Using a combination of N-ethyl-N-nitrosourea-mediated mutagenesis and metabolomics-guided screening, we identified mice with elevated blood levels of short-chain C4-acylcarnitine and increased urine isobutyryl-gl...

    Nagham George Abd Al-Ahad Sabbagha, Hsiao-Jung Kao, Chih-Fu Yang… in Pediatric Research (2011)

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  4. Article

    Open Access

    Translational control of cyclins

    Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of reg...

    Woan-Yuh Tarn, Ming-Chih Lai in Cell Division (2011)

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  5. No Access

    Article

    Cellular signals modulate alternative splicing

    Alternative splicing is a post-transcriptional mechanism that can substantially change the pattern of gene expression. Proper regulation of alternative splicing is important for cell physiology, and aberrant s...

    Woan-Yuh Tarn in Journal of Biomedical Science (2007)

  6. No Access

    Reference Work Entry In depth

    Splicing

    Chin Li, Woan-Yuh Tarn in Encyclopedic Reference of Genomics and Pro… (2006)