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  1. No Access

    Article

    The Yin–Yang of CYP3A4: a Bayesian meta-analysis to quantify inhibition and induction of CYP3A4 metabolism in humans and refine uncertainty factors for mixture risk assessment

    Quantifying differences in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. Cytochrome P450 (CYP) 3A4—the major ...

    Nadia Quignot, Witold Wiecek, Billy Amzal, Jean-Lou Dorne in Archives of Toxicology (2019)

  2. Article

    Open Access

    Cabozantinib Versus Standard-of-Care Comparators in the Treatment of Advanced/Metastatic Renal Cell Carcinoma in Treatment-naïve Patients: a Systematic Review and Network Meta-Analysis

    Cabozantinib has recently been evaluated as a first-line treatment in advanced renal cell carcinoma (aRCC).

    Elvira Schmidt, Johanna Lister, Monika Neumann, Witold Wiecek… in Targeted Oncology (2018)

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