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  1. Article

    Open Access

    Non-deforestation drivers of fires are increasingly important sources of aerosol and carbon dioxide emissions across Amazonia

    Deforestation rates have declined substantially across the Brazilian Legal Amazon (BLA) over the period from 2000–2017. However, reductions in fire, aerosol and carbon dioxide have been far less significant th...

    William T. Morgan, Eoghan Darbyshire, Dominick V. Spracklen… in Scientific Reports (2019)

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  2. No Access

    Article

    Black-carbon absorption enhancement in the atmosphere determined by particle mixing state

    Atmospheric black carbon makes an important but poorly quantified contribution to the warming of the global atmosphere. Laboratory and modelling studies have shown that the addition of non-black-carbon materia...

    Dantong Liu, James Whitehead, M. Rami Alfarra, Ernesto Reyes-Villegas… in Nature Geoscience (2017)

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    Chapter

    Contributions of Language Modeling to the Theory and Practice of Information Retrieval

    This paper presents an analysis of what language modeling (LM) is in the context of information retrieval (IR). We argue that there are two principal contributions of the language modeling approach. First, that i...

    Warren R. Greiff, William T. Morgan in Language Modeling for Information Retrieval (2003)

  4. No Access

    Article

    Effects of Reduction and Ligation of Heme Iron on the Thermal Stability of Heme-Hemopexin Complexes

    Hemopexin has two homologous domains (N- and C-terminal domains), binds 1 mole of heme per mole with high affinity (Kd < 1 pM) in a low-spin bis-histidyl complex, and acts as a transporter for the heme. Transport...

    Natalia V. Shipulina, Ann Smith, William T. Morgan in Journal of Protein Chemistry (2001)

  5. No Access

    Article

    Heme Binding by Hemopexin: Evidence for Multiple Modes of Binding and Functional Implications

    Hemopexin binds 1 mol of heme per mol with high affinity (K d < 1 pM) in a low-spin complex and acts as a transport vehicle for the heme. Circular dichroism (CD) spectroscopy was used to examine the heme environm...

    Natalia Shipulina, Ann Smith, William T. Morgan in Journal of Protein Chemistry (2000)

  6. No Access

    Article

    Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two β-propeller domains

    The ubiquitous use of heme in animals poses severe biological and chemical challenges. Free heme is toxic to cells and is a potential source of iron for pathogens. For protection, especially in conditions of t...

    Massimo Paoli, Bryan F. Anderson, Heather M. Baker… in Nature Structural Biology (1999)

  7. No Access

    Article

    Heme binding by a bacterial repressor protein, the gene product of the ferric uptake regulation (fur) gene ofEscherichia coli

    Thefur gene product, Fur, ofEscherichia coli is a repressor when it binds Fe(II). Since heme and iron metabolism are closely linked and Fur is rich in histidine, a ligand for heme, the binding of heme to Fur was ...

    Ann Smith, Nigel I. Hooper, Natalya Shipulina… in Journal of Protein Chemistry (1996)

  8. Article

    Identification of Histidine-Rich Glycoprotein in Human Colostrum and Milk

    ABSTRACT: Histidine-rich glycoprotein (HRG) is a 74− kD glycoprotein, originally discovered in plasma, whichcontains an unusually large amount of histidine (13 mol$$) and proline (13 mol%). The specific functi...

    T William Hutchens, Tai-Tung Yip, William T Morgan in Pediatric Research (1992)

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  9. No Access

    Article

    Further characterization of structural determinants of rabbit hemopexin function

    To further identify structural features of the hemopexin molecule important for its heme transport function, a fragment of the heme-binding domain (residues 1–213, Mr 35 kD, domain I) of rabbit hemopexin was o...

    Peter Muster, Fred Tatum, Ann Smith, William T. Morgan in Journal of Protein Chemistry (1991)