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Open AccessGenetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Counteri...
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Characterization of the immunoglobulin lambda chain locus from diverse populations reveals extensive genetic variation
Immunoglobulins (IGs), crucial components of the adaptive immune system, are encoded by three genomic loci. However, the complexity of the IG loci severely limits the effective use of short read sequencing, li...
