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Open AccessEpithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection
Epithelial plasticity has been suggested in lungs of mice following genetic depletion of stem cells but is of unknown physiological relevance. Viral infection and chronic lung disease share similar pathologica...
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Article
The dynamic roles of the bladder tumour microenvironment
Bladder cancer is a prevalent but currently understudied cancer type and patient outcomes are poor when it progresses to the muscle-invasive stage. Current research in bladder cancer focuses on the genetic and...
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Article
Open AccessAbnormal respiratory progenitors in fibrotic lung injury
Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage labeling have yielded identification of multiple abnormal epithelial progenitor populations during alveolar type 2 (ATII) cell d...
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Article
Macrophages, Wound Healing, and Fibrosis: Recent Insights
Macrophages are central players in the immune response following tissue injury. These cells perform many functions, and the changing tissue microenvironment during injury shapes macrophage phenotype down a var...
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Protocol
In Vitro Approaches to Assessing the Toxicity of Quantum Dots
Advances in nanotechnology have produced a new class of fluorescent nanoparticles known as quantum dots (Qdots). Compared with organic dyes and fluorescent proteins, Qdots offer several unique advantages in te...
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Article
Matrix metalloproteinase-10 plays an active role in microvascular complications in type 1 diabetic patients
The role of metalloproteinase-10 (MMP-10) in type 1 diabetes is not known. We hypothesise that it plays a role in the onset and progression of diabetic nephropathy and retinopathy.
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Article
Open AccessEpilysin (matrix metalloproteinase-28) contributes to airway epithelial cell survival
MMP28 is constitutively expressed by epithelial cells in many tissues, including the respiratory epithelium in the lung and keratinocytes in the skin. This constitutive expression suggests that MMP28 may serve...
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Book
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Matrix Metalloproteinases and Their Inhibitors in Turnover and Degradation of Extracellular Matrix
As their names imply, matrix metalloproteinases (MMPs) are thought to degrade or turnover extracellular matrix (ECM) proteins. Although some MMPs have prominent roles in ECM metabolism, most members of this la...
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Protocol
Mouse Models of MMP and TIMP Function
As their name implies, matrix metalloproteinases (MMPs) are thought to be responsible for the turnover of connective tissue proteins, a function that is indeed performed by some family members. However, matrix...
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Article
Matrix metalloproteinases as modulators of inflammation and innate immunity
Inflammation comprises the detection and response to injury and pathogens, the accumulation and intervention of cells that eliminate invading microorganisms an...
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Article
Matrix metalloproteinases in lung biology
Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been...
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Article
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes and α-defensins, ...
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Chapter
Proteases and Protease Inhibitors in Tissue Repair
Healing of wounds in the peritoneum and the skin may seem to be quite different, but at the molecular level they share many common aspects. For example, both peritoneal and skin wound healing involve inflammat...
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Chapter
Proteinases and Tissue Remodeling
The term tissue remodeling describes transient or permanent changes in tissue architecture that involve breaching of histological barriers such as basement membranes, basal laminae, and interstitial stroma [extra...
