74 Result(s)
within
Wenzhong **
Life Sciences
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Article
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport
Sterol regulatory element binding transcription factors (SREBPs) play a crucial role in lipid homeostasis. They are processed and transported to the nucleus via COPII, where they induce the expression of lipog...
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Open AccessComparative study of melasma in patients before and after treatment based on lipomics
Skin barrier alterations play a crucial function in melasma development. Past researches have demonstrated variations in lipid content between the epidermis of melasma lesions and normal tissues, along with th...
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Improving Sedum plumbizincicola genetic transformation with the SpGRF4–SpGIF1 gene and the self-excision CRE/LoxP system
S. plumbizincicola genetic transformation was optimized using a self-excision molecular-assisted transformation system by integrating the SpGRF4/SpGIF1 gene with XVE and Cre/loxP.
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Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway
Chemoresistance is a significant barrier to effective cancer treatment. Potential mechanisms for chemoresistance include reactive oxygen species (ROS) accumulation and expression of chemoresistance-promoting g...
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Combined Organic Fertilizer and Straw Return Enhanced Summer Maize Productivity and Optimized Soil Nitrate–N distribution in Rainfed Summer Maize–Winter Wheat Rotation on the Southeast Loess Plateau
Organic fertilizer and straw return are sustainable measures for increasing crop yield and improving the soil environment. The present study investigated the effects of combined organic fertilizer and straw re...
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Functional identification of anthocyanin glucosyltransferase genes: a Ps3GT catalyzes pelargonidin to pelargonidin 3-O-glucoside painting the vivid red flower color of Paeonia
Glycosylation from an anthocyanidin 3-O-glucosyltransferase Ps3GT (PsUGT78A27) facilitates the accumulation of pelargonidin 3-O-glucoside, which defines the vivid red flower color and occurs only in specific peon...
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Open AccessCuproptosis-related lncRNA signature for prognostic prediction in patients with acute myeloid leukemia
Long non-coding RNAs (lncRNAs) have been reported to have a crucial impact on the pathogenesis of acute myeloid leukemia (AML). Cuproptosis, a copper-triggered modality of mitochondrial cell death, might serve...
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Identification and Exploration of Serine Peptidase Inhibitor Kazal Type I (SPINK1) as a Potential Biomarker Correlated with the Progression of Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Although significant advances have been achieved in the treatment of NSCLC during the past two decades, the 5-year survival rate of pa...
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Open AccessCap-snatching inhibitors of influenza virus are inhibitory to the in vitro transcription of rice stripe virus
Rice stripe virus (RSV) is one of the most important viral pathogens of rice in East Asia. The transcription of RSV is initiated by cap-snatching, a mechanism shared by influenza virus (IFV). This lends the po...
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Open AccessPlant Hormone Metabolome and Transcriptome Analysis of Dwarf and Wild-type Banana
Gibberellin (GA), auxin (IAA) and brassinosteroid (BR) are indispensable in the process of plant growth and development. Currently, research on the regulatory mechanism of phytohormones in banana dwarfism is m...
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Article
Plasma membrane-nucleo-cytoplasmic coordination of a receptor-like cytoplasmic kinase promotes EDS1-dependent plant immunity
Plants use cell-surface immune receptors to recognize pathogen-specific patterns to evoke basal immunity. ENHANCED DISEASE SUSCEPTIBILITY (EDS1) is known to be crucial for plant basal immunity, whereas its act...
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Open AccessDeep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Clinical laboratories routinely use formalin-fixed paraffin-embedded (FFPE) tissue or cell block cytology samples in oncology panel sequencing to identify mutations that can predict patient response to targete...
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Open AccessAmplicon-based sequencing and co-occurence network analysis reveals notable differences of microbial community structure in healthy and dandruff scalps
Dandruff is a chronic, recurring, and common scalp problem that is caused by several etiopathogeneses with complex mechanisms. Management of this condition is typically achieved via antifungal therapies. Howev...
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Open AccessAssessing reproducibility of inherited variants detected with short-read whole genome sequencing
Reproducible detection of inherited variants with whole genome sequencing (WGS) is vital for the implementation of precision medicine and is a complicated process in which each step affects variant call qualit...
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Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
Circulating tumor DNA (ctDNA) sequencing is being rapidly adopted in precision oncology, but the accuracy, sensitivity and reproducibility of ctDNA assays is poorly understood. Here we report the findings of a...
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Open AccessA verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
Oncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of reliable genomic reference...
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Open AccessCross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized by the U.S. Food and ...
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Open AccessComparison of new hyperspectral index and machine learning models for prediction of winter wheat leaf water content
The leaf water content estimation model is established by hyperspectral technology, which is crucial and provides technical reference for precision irrigation.
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Article
Open AccessMulti-omics analysis of tumor angiogenesis characteristics and potential epigenetic regulation mechanisms in renal clear cell carcinoma
Tumor angiogenesis, an essential process for cancer proliferation and metastasis, has a critical role in prognostic of kidney renal clear cell carcinoma (KIRC), as well as a target in guiding treatment with an...
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Open AccessAuthor Correction: An extended Weight Kernel Density Estimation model forecasts COVID-19 onset risk and identifies spatiotemporal variations of lockdown effects in China
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01924-6
