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Article
Racial-Sex Disparities—A Challenging Battle Against Cancer Mortality in the USA
Decline in US cancer mortality has recently been reported, based on either pooled mortality of all cancer sites or age-adjusted mortality rates of specific sites. While the former could be dominated by a few c...
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Article
Open AccessMap** Haplotype-haplotype Interactions with Adaptive LASSO
The genetic etiology of complex diseases in human has been commonly viewed as a complex process involving both genetic and environmental factors functioning in a complicated manner. Quite often the interaction...
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Chapter
Some Critical Data Quality Control Issues of Oligoarrays
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Article
High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue
Dietary l-arginine (Arg) supplementation reduces white-fat gain in diet-induced obese rats but the underlying mechanisms are unknown. This study tested the hypothesis that Arg treatment affects expression of gene...
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Article
Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation
Increasing evidence has been gathered for p53-dependent apoptosis, but it is still unclear how p53 initiates apoptosis by employing its transcriptional program. Pair-wise interactions of p53 with expression of...
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Article
Open AccessConservation and implications of eukaryote transcriptional regulatory regions across multiple species
Increasing evidence shows that whole genomes of eukaryotes are almost entirely transcribed into both protein coding genes and an enormous number of non-protein-coding RNAs (ncRNAs). Therefore, revealing the un...
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Article
Differentiating the pathologies of cerebral malaria by postmortem parasite counts
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining pat...