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Article
Open AccessCross shard leader accountability protocol based on two phase atomic commit
Sharding blockchain is a technology designed to improve the performance and scalability of traditional blockchain systems. However, due to its design, communication between shards depends on shard leaders for ...
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Article
Open AccessPhosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant cancer with poor overall survival. The application of sorafenib is a major breakthrough in the treatment of HCC. In our study, FOXQ1 was s...
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Open AccessTunnel junctions based on interfacial two dimensional ferroelectrics
Van der Waals heterostructures have opened new opportunities to develop atomically thin (opto)electronic devices with a wide range of functionalities. The recent focus on manipulating the interlayer twist angl...
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Article
Open AccessA compact tri-notched flexible UWB antenna based on an inkjet-printable and plasma-activated silver nano ink
The rapid development of ultrawideband (UWB) communication systems has resulted in increasing performance requirements for the antenna system. In addition to a wide bandwidth, fast propagation rates and compac...
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Article
Open AccessLayout analysis of the RCEP international airline network based on hub identification using improved contribution matrix
The signing of the Regional Comprehensive Economic Partnership agreement brings new opportunities for the development of international air transportation. Faced with fierce competition, it is worth studying ho...
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Article
Open AccessUnmet Needs and Treatment Preference of Systemic Treatments for Moderate-to-Severe Psoriasis from the Perspectives of Patients and Dermatologists in China
The treatment options for moderate to severe psoriasis (msPsO) in China have been greatly increased with the approvals of biologics. However, the unmet needs and treatment preferences of systemic treatments fo...
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Article
Open AccessDevelopment and technology status of energy storage in depleted gas reservoirs
Utilizing energy storage in depleted oil and gas reservoirs can improve productivity while reducing power costs and is one of the best ways to achieve synergistic development of "Carbon Peak–Carbon Neutral" an...
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Article
Open AccessHAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway
Heart failure (HF) is a heterogeneous syndrome that affects millions worldwide, resulting in substantial health and economic burdens. However, the molecular mechanism of HF pathogenesis remains unclear.
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Open AccessRelationship between depression and burnout among nurses in Intensive Care units at the late stage of COVID-19: a network analysis
Mental health problems are critical and common in medical staff working in Intensive Care Units (ICU) even at the late stage of COVID-19, particularly for nurses. There is little research to explore the inner ...
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Article
Open AccessInsights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases
Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis and is responsible for the quality control of proteins, organelles, and energy metabolism. The E1-like ubiquitin-activa...
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Article
Open AccessHydrodynamic resistance of pore–throat structures and its effect on shale oil apparent permeability
Oil transport is greatly affected by heterogeneous pore–throat structures present in shale. It is therefore very important to accurately characterize pore–throat structures. Additionally, it remains unclear ho...
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Open AccessNanopore analysis of cis-diols in fruits
Natural fruits contain a large variety of cis-diols. However, due to the lack of a high-resolution sensor that can simultaneously identify all cis-diols without a need of complex sample pretreatment, direct and r...
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Article
Open AccessSubmesoscale variability on the edge of Kuroshio-shed eddy in the northern South China Sea observed by underwater gliders
Based on a submesoscale-resolving glider observation from April 25 to May 4, 2018, characteristics and underlying dynamics of submesoscale variability at the edge of an anticyclonic eddy shed from Kuroshio in ...
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Article
Open AccessPedigree genome data of an early-matured Geng/japonica glutinous rice mega variety Longgeng 57
By using PacBio HiFi technology, we produced over 700 Gb of long-read sequencing (LRS) raw data; and by using Illumina paired-end whole-genome shotgun (WGS) sequencing technology, we generated more than 70 Gb ...
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Open AccessThe metabolism-related lncRNA signature predicts the prognosis of breast cancer patients
Long non-coding RNAs (lncRNAs) involved in metabolism are recognized as significant factors in breast cancer (BC) progression. We constructed a novel prognostic signature for BC using metabolism-related lncRNA...
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Article
Open AccessQuantum Poisson solver without arithmetic
Solving differential equations is one of the most promising applications of quantum computing. The Poisson equation has applications in various domains of physics and engineering, including the simulation of o...
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Article
Open AccessMETTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains...
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Open AccessBreakthrough of solid tumor treatment: CAR-NK immunotherapy
As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has received increasing attention in recent years, and its safety and high efficiency have irreplaceable advantages over CAR-T. ...
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Article
Open AccessClinical evaluation of augmented reality-based 3D navigation system for brachial plexus tumor surgery
Augmented reality (AR), a form of 3D imaging technology, has been preliminarily applied in tumor surgery of the head and spine, both are rigid bodies. However, there is a lack of research evaluating the clinic...
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Open AccessRegulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the effects of secreted oncogenic mutant p53 on the tumor microen...
