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  1. Article

    Open Access

    Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant cancer with poor overall survival. The application of sorafenib is a major breakthrough in the treatment of HCC. In our study, FOXQ1 was s...

    Yiwei Liu, Ke Shao, Wendong Yang, Qi Shen, Mengru Lu, Zhiying Shao… in Cell Death & Disease (2024)

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  2. Article

    Open Access

    C-terminal modification and functionalization of proteins via a self-cleavage tag triggered by a small molecule

    The precise modification or functionalization of the protein C-terminus is essential but full of challenges. Herein, a chemical approach to modify the C-terminus is developed by fusing a cysteine protease doma...

    Yue Zeng, Wei Shi, Zhi Liu, Hao Xu, Liya Liu, Jiaying Hang… in Nature Communications (2023)

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  3. No Access

    Article

    ABCD2 Score May Discriminate Minor Stroke from TIA on Patient Admission

    With the advent of time-dependent thrombolytic therapy for ischemic stroke, it has become increasingly important to differentiate transient ischemic attack (TIA) from minor stroke patients after symptom onset ...

    Hui Zhao, Qingjie Li, Mengru Lu, Yuan Shao, **gwei Li… in Translational Stroke Research (2014)