8 Result(s)

Article

Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss and accounts for a major source of pain and disability worldwide. However, effective strategies for cartilage repai...

Yuangang Wu, Jiao Li, Yi Zeng, Wenchen Pu… in International Journal of Oral Science (2022)

Article

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin l...

**nyi Li, Wenchen Pu, Qingquan Zheng, Min Ai, Song Chen, Yong Peng in Molecular Cancer (2022)

Article

Cysteine-113 covalency inspires the development of Pin1 inhibitor

Wenchen Pu, Jiao Li, Yong Peng in Signal Transduction and Targeted Therapy (2020)

Article

Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer

Cancer-associated chromosomal translocations are reported to generate oncogenic circular RNA (circRNA), contributing to tumorigenesis. The fusion gene SLC34A2-ROS1 (solute carrier family 34 member 2 and ROS proto...

Ke Wu, Xun Liao, Youling Gong, Juan He, Jian-Kang Zhou, Shuangyan Tan… in Molecular Cancer (2019)

Article

Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer

Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrat...

Shuangyan Tan, Dan Sun, Wenchen Pu, Qiheng Gou, Chenglin Guo… in Molecular Cancer (2018)