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Article
Open AccessGSDME-mediated pyroptosis promotes anti-tumor immunity of neoadjuvant chemotherapy in breast cancer
Paclitaxel and anthracycline-based chemotherapy is one of the standard treatment options for breast cancer. However, only about 6–30% of breast cancer patients achieved a pathological complete response (pCR), ...
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Article
AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death
BH3 mimetics, including the BCL2/BCLXL/BCLw inhibitor navitoclax and MCL1 inhibitors S64315 and tapotoclax, have undergone clinical testing for a variety of neoplasms. Because of toxicities, including thrombocyto...
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Article
Open AccessA wearable patch for continuous analysis of thermoregulatory sweat at rest
The body naturally and continuously secretes sweat for thermoregulation during sedentary and routine activities at rates that can reflect underlying health conditions, including nerve damage, autonomic and met...
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Article
Anti-vibration design for TBM main drive system based on multi-directional coupling dynamic characteristics analysis
Extreme vibration often occurs on TBM main system during the tunneling process. This paper established the mathematical model for TBM main system considering the impact load, time-varying internal incentive an...