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  1. Article

    Open Access

    XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

    Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

    Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

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  2. No Access

    Article

    GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion

    Lung cancer is the leading cause of cancer-related death worldwide. Glypican-5 (GPC5) is a member of heparan sulfate proteoglycans, and its biological importance in initiation and progression of lung cancer re...

    **n Yang, Yan Chen, You Zhou, Chen Wu, Qing Li, Jun Wu, Wen Wei Hu… in Oncogene (2021)

  3. Article

    Open Access

    Co-mutations of TP53 and KRAS serve as potential biomarkers for immune checkpoint blockade in squamous-cell non-small cell lung cancer: a case report

    Unprecedented durable responses are identified in clinical studies to target the signaling of programmed cell death protein-1 (PD-1) as well as its ligand (PD-L1) in patients with squamous-cell non-small cell ...

    Cheng Fang, Chu Zhang, Wei-Qing Zhao, Wen-Wei Hu, Jun Wu, Mei Ji in BMC Medical Genomics (2019)

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  4. Article

    Open Access

    Pulmonary immune responses to 2009 pandemic influenza A (H1N1) virus in mice

    Well-characterized mice models will afford a cheaper, easy-handling opportunity for a more comprehensive understanding of 2009 influenza A (H1N1) virus’s pathogenesis potential. We aimed to provide a robust de...

    ** Lv, Dan Wang, Yan-Hong Hua, Shi-Jia Pei, ** Wang… in BMC Infectious Diseases (2014)

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  5. No Access

    Article

    Circadian variability of pharmacokinetics of cisplatin in patients with non-small-cell lung carcinoma: analysis with the NONMEM program

    The aim of this study was to describe the nonlinear pharmacokinetics of total and unbound plasma cisplatin under different administered time in patients with non-small-cell lung carcinoma.

    Rong Chen, Jie Li, Wen-wei Hu, Ming-li Wang… in Cancer Chemotherapy and Pharmacology (2013)

  6. No Access

    Article

    Molecular characterization of a Phi-class mustard (Brassica juncea) glutathione S-transferase gene in Arabidopsis thaliana by 5′-deletion analysis of its promoter

    Glutathione S-transferases (GSTs) are regulated by various stimuli at the transcriptional level. In this study, a 2,640-bp promoter sequence of a mustard GST gene, BjGSTF2, was cloned. Several truncated BjGSTF2 p...

    Haibiao Gong, Wen-Wei Hu, Yuxia Jiao, Eng-Chong Pua in Plant Cell Reports (2005)

  7. No Access

    Article

    Expression of glutathione-S-transferase and its role in plant growth and development in vivo and shoot morphogenesis in vitro

    The enzymes glutathione-S-transferases (GSTs, E.C.2.5.1.18) have been associated with detoxification of xenobiotics, limiting oxidative damage and other stress responses in plants. In this study, we report the is...

    Haibiao Gong, Yuxia Jiao, Wen-wei Hu, Eng-Chong Pua in Plant Molecular Biology (2005)