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Article
Biochemical Content, Antimicrobial, and Larvicidal Activities of Jiaosu Derived from Different Combinations of Fruit Wastes
Valorization of fruit wastes through fermentation yields a multipurpose liquid called jiaosu. This study was conducted to compare the biochemical content changes (pH, total proteins, total carbohydrates, total...
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Article
Energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole
To investigate the energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole, we utilized a nanosecond resolution photography system based on a Q-switched Nd: YAG lase...
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Article
Selective and quasi-continuous switching of ferroelectric Chern insulator devices for neuromorphic computing
Quantum materials exhibit dissipationless topological edge state transport with quantized Hall conductance, offering notable potential for fault-tolerant computing technologies. However, the development of top...
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Article
Open AccessDisrupted gut microecology after high-dose 131I therapy and radioprotective effects of arachidonic acid supplementation
Despite the potential radiotoxicity in differentiated thyroid cancer (DTC) patients with high-dose 131I therapy, the alterations and regulatory mechanisms dependent on intestinal microecology remain poorly unders...
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Article
Open AccessA pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...
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Article
Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study
The obesity paradox has been reported among older adults. However, whether the favorable effect of obesity is dependent on metabolic status remains largely unknown. We aimed to explore the association of metab...
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Article
Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration
Methamphetamine (MA) is one of the most abused drugs globally, but the mechanism of its addiction remains unclear. Several animal studies have shown that the gut microbiota (GM) influences addictive behaviors,...
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Article
Open AccessCholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated promising efficacy in early trials for relapsed/refractory diffuse large B cell lymphoma (DLBCL). However, its efficacy in treating primary ref...
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Article
Open AccessSmooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis
Hyperglycemia accelerates calcification of atherosclerotic plaques in diabetic patients, and the accumulation of advanced glycation end products (AGEs) is closely related to the atherosclerotic calcification. Her...
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Article
Open AccessAssociation between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer
Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...
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Article
Fabrication of Tremella-Like Zn-Based Composite Coating with Improved Photocatalytic Degradation Performance and Robust Superhydrophobicity
In this paper, as-received Zn powder and as-prepared Zn@(ZnWO4/ZnO) core–shell powder were used as feedstocks for plasma spraying to prepare Zn-based composite coatings and nano-ZnO was co-deposited by chemical v...
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Article
Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy
To examine the pattern of kisspeptin expression throughout the menstrual cycle in polycystic ovary syndrome (PCOS) patients under the ovulation induction and identify any possible associations with early pregn...
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Article
Open AccessAnalysis of the association between high antioxidant diet and lifestyle habits and diabetic retinopathy based on NHANES cross-sectional study
Oxidative stress plays a crucial role in increasing the risk of develo** diabetic retinopathy (DR). The oxidative balance score (OBS) and the composite dietary antioxidant index (CDAI) are two tools for asse...
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Article
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation
Primary Sjögren’s syndrome (pSS) is a chronic inflammatory autoimmune disease with an unclear pathogenesis, and there is currently no approved drug for the treatment of this disease. Iguratimod, as a novel cli...
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Article
Open AccessTargeting tumor suppressor p53 for organ fibrosis therapy
Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor suppressor p53 (p53), known for its ...
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Article
Observation of spectral lines in the exceptional GRB 221009A
As the brightest gamma-ray burst ever observed, GRB 221009A provided a precious opportunity to explore spectral line features. In this article, we performed a comprehensive spectroscopy analysis of GRB 221009A...
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Article
Open AccessMeasurement of Born cross section of \( {e}^{+}{e}^{-}\to {\Sigma}^{+}{\overline{\Sigma}}^{-} \) at center-of-mass energies between 3.510 and 4.951 GeV
Using 24.1 fb−1 of e+e− collision data collected with the BESIII detector at the BEPCII collider, the Born cross sections and effective form factors of the ...
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Article
Open AccessA novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer
Breast cancer (BC) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. The 5-year survival rate is over 90% in BC patients, but once BC cells metastasis into distal org...
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Article
Anti-MRSA Pyrone Derivative Products Isolated from Plant-Derived Fungus Aspergillus niger Pas67
A new pyrone derivative 11-hydroxypyrophen (1), together with pyrophen (2) and six naphtho-γ-pyrones (3–8), were obtained from the culture extract of Aspergillus niger Pas67. All isolated compounds were evaluated...
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Article
A critical appraisal of clinical practice guidelines on surgical treatments for spinal metastasis
As an important treatment for spinal metastasis, surgery has strict applicable conditions. Although various organizations have formulated different guidelines on surgical treatment for spinal metastasis (SM), ...
