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Article
Open AccessA pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...
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Article
Open AccessVisualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens
The potential role of the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR), within the nucleus accumbens (NAcc) in regulating drug addiction and feeding has been documented; howe...
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Article
SNHG4-mediated PTEN destabilization confers oxaliplatin resistance in colorectal cancer cells by inhibiting ferroptosis
Oxaliplatin resistance poses a significant challenge in colorectal cancer (CRC) therapy, necessitating further investigation into the underlying molecular mechanisms. This study aimed to elucidate the regulato...
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Article
Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature
Bioluminescent probes are widely used to monitor biomedically relevant processes and cellular targets in living animals. However, the absorption and scattering of visible light by tissue drastically limit the ...
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Article
Open AccessPosterior capsular radial sign: a novel method to confirm anterior vitreous cortex resection in phacovitrectomy
The main purpose of this paper is to introduce a method that can accurately locate the posterior capsule of the lens to facilitate a relatively complete resection of the anterior vitreous body.
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Article
Open AccessA novel hybrid model for species distribution prediction using neural networks and Grey Wolf Optimizer algorithm
Neural networks are frequently employed to model species distribution through backpropagation methods, known as backpropagation neural networks (BPNN). However, the complex structure of BPNN introduces paramet...
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Article
Augmented fluoroscopy-guided dye localization for small pulmonary nodules in hybrid operating room: intrathoracic stam** versus transbronchial marking
We developed a novel augmented fluoroscopy-guided intrathoracic stam** technique for localizing small pulmonary nodules in the hybrid operating room. We conducted an observational study to investigate the fe...
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Article
Grain size effect on plastic microformation behavior for Inconel 718 foils: Experiment and modeling
With the rapid development of the aerospace industry, there is an increasing demand for miniaturized parts made of Inconel 718 foils. However, the grain size effect on the plastic deformation behavior of thin ...
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Open AccessComplement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
Repeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane-induced neurotoxicity and explore the underlyin...
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Article
Open AccessPredictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study
Clinical practice guidelines on limitation of life-sustaining treatments (LST) in the intensive care unit (ICU), in the form of withholding or withdrawal of LST, state that there is no ethical difference betwe...
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Article
Streptococcus taonis sp. nov., a novel bacterial species isolated from a blood culture of a patient
One Gram stain-positive, catalase-negative, α-hemolytic, chain-forming or paired cocci, designated ST22-14T, was isolated from a blood culture of a child with suspected infection. The results of 16S rRNA gene seq...
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Article
Open AccessRNA structure profiling at single-cell resolution reveals new determinants of cell identity
RNA structure is critical for multiple steps in gene regulation. However, how the structures of transcripts differ both within and between individual cells is unknown. Here we develop a SHAPE-inspired method c...
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Article
Open AccessCT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD
Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance...
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Article
Open AccessRepositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulator, plays an essential role in allergic pulmonary inflammation in mice. Treatment with a VIST...
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Open AccessRetraction Note: Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway
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Article
Open AccessCo-designing care for multimorbidity: a systematic review
The co-design of health care enables patient-centredness by partnering patients, clinicians and other stakeholders together to create services.
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Article
Distributed asynchronous non-smooth optimization with coupled equality and bounded constraints
This paper considers a distributed convex optimization problem with a linearly coupled equality constraint and non-smooth objective function, in which heterogeneous time delays exist over the communication net...
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Article
Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson’s disease
Cell senescence has been implicated in the pathology of Parkinson’s disease (PD). Both abnormal α-synuclein aggregation and iron deposition are suggested to be the triggers, facilitators, and aggravators durin...
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Article
Fatty acid metabolism-related molecular subtypes and a novel model for predicting prognosis in bladder cancer patients
This study aims to develop fatty acid metabolism-related molecular subtypes and construct a fatty acid metabolism-related novel model for bladder cancer (BCa) by bioinformatic profiling. Genome RNA-seq express...
