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Article
Open AccessThe nomogram based on the 6-lncRNA model can promote the prognosis prediction of patients with breast invasive carcinoma
Long non-coding RNA (lncRNA) is a prognostic biomarker for many types of cancer. Here, we aimed to study the prognostic value of lncRNA in Breast Invasive Carcinoma (BRCA). We downloaded expression profiles fr...
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Article
Maternal Smoking and Infant Low Birth Weight: Exploring the Biological Mechanism Through the Mother’s Pre-pregnancy Weight Status
Maternal smoking has been found to adversely affect birth outcomes, such as increasing the odds of having low birth weight infants. However, the mechanisms explaining how a mother’s smoking is linked to a chil...
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Article
Open AccessIntestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation
The gut microbiota participates in the metabolism of substances and energy, promotes the development and maturation of the immune system, forms the mucosal barrier, and protects the host from pathogen attacks....
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Protocol
Gene Silencing of Human Sertoli Cells Utilizing Small Interfering RNAs
Sertoli cells, as the unique somatic cells within the seminiferous tubules, play essential roles in regulating normal spermatogenesis. In addition, recent studies have demonstrated that Sertoli cells could hav...
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Article
Sensitivity of Liquation Cracking to Deposition Parameters and Residual Stresses in Laser Deposited IN718 Alloy
The laser deposited IN718 alloys were fabricated with laser cladding system under different conditions to estimate the sensitivity of weld metal liquation cracking. The microstructure and the crack characteriz...
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Article
Open AccessIs preoperative MRCP necessary for patients with gallstones? An analysis of the factors related to missed diagnosis of choledocholithiasis by preoperative ultrasound
The diagnosis of associated choledocholithiasis prior to cholecystectomy for patients with gallstones is important for the surgical decision and treatment efficacy. However, whether ultrasound is sufficient fo...
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Article
Role of vitamin D receptor gene polymorphisms in pancreatic cancer: a case–control study in China
The study was conducted to investigate the relationship between vitamin D receptor (VDR) gene rs2228570 and rs1544410 polymorphisms and pancreatic cancer (PC). Two hundred fifty-eight PC patients and 385 healt...
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Article
Open AccessDatabase screening of herbal monomers regulating autophagy by constructing a "disease-gene-drug" network
Studies suggest an important role of autophagy as a target for cancer therapy. We constructed a "disease-gene-drug" network using the modular approach of bioinformatics and screened herbal monomers demonstrati...
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Article
Modular Analysis of Bioinformatics Demonstrates a Critical Role for NF-κB in Macrophage Activation
To achieve the goal of identifying the gene groups that regulated macrophage activation, a total of 925 differentially expressed genes of activated macrophages were found at the intersection of the three serie...
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Article
Proteomic analysis of apoptotic and oncotic pancreatic acinar AR42J cells treated with caerulein
This study aims to determine the differentially expressed proteins in the pancreatic acinar cells undergoing apoptosis and oncosis stimulated with caerulein to explore different cell death process of the acina...
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Article
Metabolomic study of serum from rabbits with acute acalculous cholecystitis
1H-NMR is a powerful approach of metabolomics. This study aimed to apply it to detect the serum metabolites in rabbits with acute acalculous cholecystitis (AAC), and to analyze their potential ...
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Chapter and Conference Paper
Handling Multi-optimization with Gender-Hierarchy Based Particle Swarm Optimizer
In this study, we present a novel particle swarm optimizer, called Gender-Hierarchy Based Particle Swarm Optimizer (GH-PSO), to handle multi-objective optimization problems. By employing the concepts of gender...
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Article
Open AccessCarbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
Hepatic ischemia-reperfusion injury (I/Ri) is a serious complication occurring during liver surgery that may lead to liver failure. Hepatic I/Ri induces formation of reactive oxygen species, hepatocyte apoptos...
