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Article
Open AccessRUNX transcription factors: biological functions and implications in cancer
Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes. Their most widely recognized role in malignancy is to promot...
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Article
Open AccessDevelopment of a novel immune-related lncRNA prognostic signature for patients with hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common neoplasm and the major cause of cancer-associated death worldwide. The high mortality rate of HCC is mainly attributed to its widespread prevalence and the lac...
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Article
Open AccessThe kinase p38α functions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation
Dendritic cells (DCs) play a critical role in controlling T helper 2 (Th2) cell-dependent diseases, but the signaling mechanism that triggers this function is not fully understood. We showed that p38α activity...
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Article
Open AccessAnnexin A1 promotes the progression of bladder cancer via regulating EGFR signaling pathway
Bladder cancer (BLCA) is one of the most common malignancies worldwide. One of the main reasons for the unsatisfactory management of BLCA is the complex molecular biological mechanism. Annexin A1 (ANXA1), a Ca2+-...
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Chapter and Conference Paper
Model Free Auxiliary Control Strategy Based on Heuristic Dynamic Programming for SGCMG Gimbal Servo System
In the operation of some satellite systems, single gimbal control moment gyroscope (SGCMG) is always applied in the attitude control tasks. The control of SGCMG is mostly driven by using permanent magnet synch...
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Article
Open AccessOrganoid technology in disease modelling, drug development, personalized treatment and regeneration medicine
Organoid technology bridges the gap between conventional two-dimensional cell line culture and in vivo models. The near-physiological technology can virtually recapitulates organ development and human diseases...
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Article
Open AccessThe role of neoantigen in immune checkpoint blockade therapy
Immune checkpoint inhibitor induces tumor rejection by activated host immune system. The anti-tumor immune response consists of capture, presentation, recognition of neoantigen, as well as subsequent killing o...
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Article
Open AccessOrganoid technology and applications in cancer research
During the past decade, the three-dimensional organoid technology has sprung up and become more and more popular among researchers. Organoids are the miniatures of in vivo tissues and organs, and faithfully re...
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Article
Open AccessBiomarkers for predicting efficacy of PD-1/PD-L1 inhibitors
Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD-1/PD-L1 axis plays a crucial role in ...
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Article
Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection
Multidrug-resistant Acinetobacter baumannii, a common pathogen responsible for nosocomial infections, is the main cause for outbreaks of infectious diseases, such as pneumonia, meningitis, and bacteremia, especia...
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Article
Open AccessGut microbiome modulates efficacy of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) therapy is a novel strategy for cancer treatments in recent years. However, it was observed that most patients treated with ICIs could not get benefit from the therapy, whic...
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Article
Open AccessEGFR-TKIs resistance via EGFR-independent signaling pathways
Tyrosine kinase inhibitors (TKIs)-treatments bring significant benefit for patients harboring epidermal growth factor receptor (EGFR) mutations, especially for those with lung cancer. Unfortunately, the majori...
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Article
Open AccessDevelopment and clinical application of anti-HER2 monoclonal and bispecific antibodies for cancer treatment
HER2-targeted immunotherapy consists of monoclonal antibodies (e.g. trastuzumab, pertuzumab), bispecific antibodies (e.g. MM-111, ertumaxomab) and activated T cells armed with anti-HER2 bispecific antibody (HE...
