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Article
Find and replace: editing human genome in pluripotent stem cells
Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and develo** future medicine. Recently a number of independent genome-editing techniques were devel...
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Article
Converted neural cells: induced to a cure?
Many neurodegenerative disorders such as Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many...
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Article
Non-viral iPSCs: a safe way for therapy?
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Article
DNA methylome: Unveiling your biological age
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on t...
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Article
Open AccessInflammasomes in cancer: a double-edged sword
Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers ...
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Article
Open AccessROR1, an embryonic protein with an emerging role in cancer biology
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Wit...
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Article
Open AccessCharacterization of a novel mouse model with genetic deletion of CD177
Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue in response to infection. Recently, a neutrophil cell surface receptor, C...
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Article
Open AccessVitamin C alleviates aging defects in a stem cell model for Werner syndrome
Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). ...
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Article
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies ...
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Article
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling
Aiming to identify immune molecules with a novel function in cancer pathogenesis, we found the cluster of differentiation 177 (CD177), a known neutrophil antigen, to be positively correlated with relapse-free, me...
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Article
Open AccessBody fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study
Energy imbalance has an important role in breast cancer prognosis. Hyperactive mechanistic Target of Rapamycin (mTOR) pathway is associated with breast tumor growth, but the extent to which body fatness is ass...