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Article
Clinical and genetic analysis for four Chinese families with Prader–Willi syndrome
Prader–Willi syndrome (PWS) is a complex, genetic, multisystem disorder. Its major clinical features include neonatal hypotonia and failure to thrive, mental retardation, hypogonadism, short hands and feet, hy...
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Article
Insulin sensitivity and first-phase insulin secretion in obese Chinese with hyperglycemia in 30 and/or 60 min during glucose tolerance tests
The purpose of this study was to investigate insulin sensitivity and first-phase insulin secretion in obesity with hyperglycemia in 30 and/or 60 min during oral glucose tolerance (OGTT, glucose ≥ 11.1 mmol/l, ...
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Article
Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes
In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingl...
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Article
Clinical and genetic analysis for a Chinese family with hereditary fructose intolerance
Hereditary fructose intolerance (HFI) is an inheritable disorder of fructose metabolism, inherited as an autosomal recessive disorder and caused by catalytic deficiency of aldolase B, which is critical for glu...
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Article
The interplay of insulin resistance and β-cell dysfunction involves the development of type 2 diabetes in Chinese obeses
Type 2 diabetes mellitus (T2DM) is a heterogeneous disorder characterized by defects in insulin secretion and action and obesity plays an important role in the deterioration of glucose metabolism. In the prese...
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Article
Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome
Overproduction of proinflammatory factors is associated with obesity and diabetes. Interleukin (IL)-18 as a member of IL-1 cytokine family is increased in obese, in diabetic, and even in polycystic ovary syndr...
