-
Article
Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation
Sleep deprivation (SD) is increasingly common in modern society, which can lead to the dysregulation of inflammatory responses and cognitive impairment, but the mechanisms remain unclear. Emerging evidence sug...
-
Article
Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects
Immune dysregulation, specifically of inflammatory processes, has been linked to behavioral symptoms of depression in both human and rodent studies. Here, we evaluated the antidepressant effects of immunizatio...
-
Article
Correction: EphB2 in the medial prefrontal cortex regulates vulnerability to stress
Following publication of the above article, the authors noticed that an incorrect version of Figs. 2f, 3f, 5h and 7d was presented.
-
Article
EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress
The ephrin B2 (EphB2) receptor is a tyrosine kinase receptor that is associated with synaptic development and maturation. It has recently been implicated in cognitive deficits and anxiety. However, still unkno...
-
Article
Open AccessmTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine
Neuropeptides play important roles in modulating the rewarding value of abused drugs. Trefoil factor 3 (TFF3) was recently reported to modulate withdrawal syndrome of morphine, but the effects of TFF3 on the c...
-
Article
Open AccessA novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking
We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-con...
-
Article
Neuropeptide trefoil factor 3 attenuates naloxone-precipitated withdrawal in morphine-dependent mice
The persistence of physical dependence and craving in addicts is considered to contribute to relapse. Increasing evidence indicates that neuropeptide systems are associated with several phases of drug addictio...
-
Article
Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats
A conditioned stimulus (CS) is associated with a fearful unconditioned stimulus (US) in the traditional fear conditioning model. After fear conditioning, the CS–US association memory undergoes the consolidatio...
-
Article
Hippocampal CLOCK protein participates in the persistence of depressive-like behavior induced by chronic unpredictable stress
Circadian disturbances are strongly linked with major depression. The circadian proteins CLOCK and BMAL1 are abundantly expressed but function differently in the suprachiasmatic nucleus (SCN) and hippocampus. ...
-
Article
PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3
Depression is one of the most common and debilitating psychiatric illnesses around the world, but the current antidepressants used to treat depression have many limitations. Progressively more studies have sho...
-
Article
Role of calcineurin in the VTA in rats behaviorally sensitized to methamphetamine
Chronic psychostimulant administration increases locomotor activity, which is referred to as locomotor sensitization. Calcineurin has been suggested to participate in psychostimulant-induced sensitization, but...
