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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
Open AccessAntibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study
It is controversial whether antibiotic should be used prophylactically 48 h after pancreatic surgery. Hence, the association of antibiotic prophylaxis (AP) after 48 h postoperatively with the incidence of surg...
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Article
Topology optimization of gradient lattice structure under harmonic load based on multiscale finite element method
This work develops a topological optimization framework for parametric lattice structure design under harmonic load based on the scale-dependent multiscale finite element method (MsFEM). Two different design v...
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Article
Open AccessMaternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China
Congenital heart defects (CHDs) are a major global health problem, yet their crucial environmental risk factors are still unclear. We aimed to explore the associations between maternal periconceptional environ...
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Article
Open AccessEight-year experience of maternal death surveillance in Morocco: qualitative study of stakeholders’ views at a subnational level
Since 2009, Morocco has been implementing the Maternal Death Surveillance System (MDSS). The results obtained indicate significant regional variations in terms of implementation stage, completeness of maternal...
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Article
Shape preserving design with topology optimization for structures under harmonic resonance responses
For a structural system composed of functional components in a vibration environment, it is of great importance to suppress the dynamic war** deformation of these local regions to ensure the performance and ...
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Article
Concurrent optimization of sandwich structures lattice core and viscoelastic layers for suppressing resonance response
This paper studies the optimization design of sandwich structures with lattice core and viscoelastic layers for suppressing structural resonance response in the frequency domain. A concurrent optimization sche...
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Article
Mitigation of chatter in thin-wall milling by using double-side support device
This article develops a new method to mitigate chatter vibrations in the thin-wall milling of the structures with half-opened side walls through designing a supplementary device, which can provide double-side ...
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Article
Minimum residual modified HSS iteration method for a class of complex symmetric linear systems
For solving a class of complex symmetric system of linear equations, we apply the minimum residual technique to the modified Hermitian and skew-Hermitian splitting (MHSS) iteration scheme and propose an iterat...
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Article
Open AccessWomen’s cancers in China: a spatio-temporal epidemiology analysis
Women's cancers, represented by breast and gynecologic cancers, are emerging as a significant threat to women's health, while previous studies paid little attention to the spatial distribution of women's cance...
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Article
Open AccessHealth-related quality of life and its related factors in coronary heart disease patients: results from the Henan Rural Cohort study
The aims were to identify the possible influencing factors of health-related quality of life (HRQoL) and its domain-specific scores in patients with coronary heart disease (CHD). A total of 1247 patients with ...
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Article
Open AccessSexual health and COVID-19: protocol for a sco** review
Global responses to the COVID-19 pandemic have exposed and exacerbated existing socioeconomic and health inequities that disproportionately affect the sexual health and well-being of many populations, includin...
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Article
Amorphous Nickel Phosphide Nanoparticles for Selective Hydrogenation of Cinnamaldehyde
The selective hydrogenation of α,β-unsaturated aldehydes plays a crucial role in industrial production, and an efficient non-noble metal catalyst for it has been pursued to reduce the cost. Herein, we report a...
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Article
Open AccessSexual and reproductive health correlates of polysubstance use among female adolescents who sell sex in the southwest of China
Substance use and adverse sexual and reproductive health (SRH) outcomes continue to be significant threats to female adolescents’ health and wellbeing, particularly to these marginalized subpopulations. Our re...
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Article
Simple stop** criteria for the LSQR method applied to discrete ill-posed problems
The LSQR iterative method is one of the most popular numerical schemes for computing an approximate solution of large linear discrete ill-posed problems with an error-contaminated right-hand side, which repres...
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Article
The Prediction Model of Warfarin Individual Maintenance Dose for Patients Undergoing Heart Valve Replacement, Based on the Back Propagation Neural Network
Because of the narrow therapeutic window and huge inter-individual variation, the individual precision on anticoagulant therapy of warfarin is challenging. In our study, we aimed to construct a Back Propagatio...
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Article
A tunable passive damper for suppressing chatters in thin-wall milling by considering the varying modal parameters of the workpiece
Removal of the materials during thin-wall milling leads to obvious change of the modal parameters of the thin-walled workpiece. This article proposes a new method for designing a passive damper to suppress the...
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Article
Association between weekday sleep duration and nonmedical use of prescription drug among adolescents: the role of academic performance
Nonmedical use of prescription drug (NMUPD) among adolescents has increased substantially over the last 2 decades, and evidence suggests that sleep duration may impact upon drug use and academic performance. T...
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Article
Immobilized amino-containing basic ionic liquid on graphene oxide as an efficient and stable catalyst for transesterification
A basic ionic liquid containing aminopropylimidazolium moiety and OH‒ anion was immobilized on silane-functionalized graphene oxide (GO) by a condensation process, followed by an anion-exchange reaction. The prop...
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Article
Distribution of Phosphorus and Its Effects on Precipitation Behaviors and Tensile Properties of IN718C Cast Superalloy
The effect of phosphorus on the precipitations of γ″, γ′ and δ phases and associated tensile properties in IN718C alloy are investigated in this study. It is revealed that P atoms are dissolved in the grain in...
