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  1. Article

    Open Access

    Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity

    Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is generally thought to be involved. Here we show multiple lines of evidence supporting that modulation of the sleep–wa...

    Wanling Peng, **aotong Liu, Guofen Ma, Zhaofa Wu, Ziyue Wang, **ang Fei… in Cell Discovery (2023)

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  2. Article

    Open Access

    REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex

    The cerebral cortex is spontaneously active during sleep, yet it is unclear how this global cortical activity is spatiotemporally organized, and whether such activity not only reflects sleep states but also co...

    Ziyue Wang, **ang Fei, **aotong Liu, Yanjie Wang, Yue Hu… in Nature Communications (2022)

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  3. Article

    Open Access

    A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging

    cAMP is a key second messenger that regulates diverse cellular functions including neural plasticity. However, the spatiotemporal dynamics of intracellular cAMP in intact organisms are largely unknown due to l...

    Liang Wang, Chunling Wu, Wanling Peng, Ziliang Zhou, Jianzhi Zeng… in Nature Communications (2022)

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  4. No Access

    Article

    Cardiac Expression of Esophageal Cancer-Related Gene-4 is Regulated by Sp1 and is a Potential Early Target of Doxorubicin-Induced Cardiotoxicity

    Esophageal Cancer-Related Gene 4 (Ecrg4) expressed in cardiomyocytes and the cardiac conduction system is downregulated during cardiac ischemia and atrial fibrillation. To explore whether Ecrg4 plays any role ...

    Dandan Long, Chunyue Chen, Wei Li, Wanling Peng, Dongmei Li… in Cardiovascular Toxicology (2022)

  5. No Access

    Article

    A genetically encoded sensor for measuring serotonin dynamics

    Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating important processes in the brain. To directly visualize the release of 5-HT, we developed a genetically encoded G-protein-...

    **xia Wan, Wanling Peng, Xuelin Li, Tongrui Qian, Kun Song… in Nature Neuroscience (2021)

  6. No Access

    Article

    An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

    The ability to directly measure acetylcholine (ACh) release is an essential step toward understanding its physiological function. Here we optimized the GRABACh (GPCR-activation-based ACh) sensor to achieve substa...

    Miao **g, Yuexuan Li, Jianzhi Zeng, Pengcheng Huang, Miguel Skirzewski… in Nature Methods (2020)

  7. No Access

    Article

    Study on the Effect of Kidney Transplantation on the Health of the Patients’ Offspring: A Report on 252 Chinese Children

    Even though the incidence of pregnancies in the female recipients is lower and also chronic renal disease in male patients is associated with impaired spermatogenesis, the health of the children born to these ...

    Longgen Xu, Peng Han, Yong Liu, Hongwei Wang… in Cell Biochemistry and Biophysics (2014)