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Article

Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics

Antibiotic resistance is becoming one of the major crises, among which hydrolysis reaction is widely employed by bacteria to destroy the reactive pharmacophore. Correspondingly, antibiotic producer has canonic...

Wan-Hong Wen, Yue Zhang, Ying-Ying Zhang, Qian Yu, Chu-Chu Jiang… in Nature Communications (2021)