28 Result(s)
within
Walter Stummer
Neurology
Oncology
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Article
Open AccessCorrection to: Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
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Article
Open AccessMaximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
Maximal cardiopulmonary exercise testing (max. CPET) provides the most accurate measurement of cardiorespiratory fitness. However, glioblastoma (GBM) patients often undergo less intensive tests, e.g., 6-min wa...
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Article
Open AccessThe importance of considering competing risks in recurrence analysis of intracranial meningioma
The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided by using the Aalen-Johansen method, w...
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Article
Open AccessCorrection to: Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses
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Open AccessUndetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses
In the randomized CeTeG/NOA-09 trial, lomustine/temozolomide (CCNU/TMZ) was superior to TMZ therapy regarding overall survival (OS) in MGMT promotor-methylated glioblastoma. Progression-free survival (PFS) and...
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Article
Molecular predictors for decitabine efficacy in meningiomas – a pilot study
Effective chemotherapeutical agents for the treatment of meningiomas are still lacking. Previous in-vitro analyses revealed efficacy of decitabine (DCT), a DNA methyltransferase (DNMT) inhibitor established in...
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Open AccessConceptual development of an intensive exercise program for glioma patients (ActiNO): summary of clinical experience
Exercise proved to reduce cancer-related symptoms and prolong survival in some cancer types. However, brain tumor patients are often advised against strenuous exercise. Here, we summarize our experience with a...
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Article
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas
Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescenc...
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Article
Established and emerging uses of 5-ALA in the brain: an overview
5-aminolevulinic acid (5-ALA) was approved by the FDA in June 2017 as an intra-operative optical imaging agent for patients with gliomas (suspected World Health Organization Grades III or IV on preoperative im...
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Article
5-ALA fluorescence-guided surgery of CNS tumors
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Article
5-ALA and FDA approval for glioma surgery
The US Food and Drug Administration (FDA) approved 5-aminolevulinic acid (5-ALA; Gleolan®; photonamic GmbH and Co. KG) for use as an intraoperative optical imaging agent in patients with suspected high-grade glio...
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Article
Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas
Fluorescence guided surgery has developed over the last 2 decades as a formidable augmentation strategy to promote maximal safe resection and diagnostic accuracy within gliomas. The majority of the literature ...
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Open AccessCombined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients
There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses.
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Article
Simpson grade IV resections of skull base meningiomas: does the postoperative tumor volume impact progression?
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Article
Initial psycho-oncological counselling in neuro-oncology: analysis of topics and needs of brain tumour patients
Diagnosis of a brain tumour is associated with a tremendous disruption of emotional, physical and social well-being. Due to the complexity of the disease and the affection of the central organ, the brain, brai...
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Fluoreszenzgestützte Gliomresektion
Die spezifische intraoperative Visualisierung hirneigener Tumoren ist mit Aminolävulinsäure (ALA) erstmals praktikabel geworden. Der Stellenwert der Methode ist bei malignen Gliomen in Form verlängerter Überle...
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The Simpson grading in meningioma surgery: does the tumor location influence the prognostic value?
In meningiomas, location-specific differences of the prognostic value of the Simpson classification are sparsely investigated but can influence strategy of surgery. We therefore compared the prognostic value o...
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Article
hTERT promoter methylation in meningiomas and central nervous hemangiopericytomas
In meningiomas, prognostic impact of mutations in the human telomerase reverse transcriptase (hTERT) promoter region was recently shown, while studies of promoter methylation and analyses of hemangiopericytomas a...
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Chapter
Advanced Imaging Modalities and Treatment of Gliomas: Neurosurgery
Current data warrant cytoreductive surgical approaches in low as well as high grade gliomas. Surgical aims vary depending on histology – speed of growth and impending malignant transformation being major aspec...
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hTERT promoter methylation in pituitary adenomas
Telomerase reverse transcriptase (TERT) expression is a hallmark in tumorigenesis and upregulated due to mutations and methylation of the human (h)TERT promoter. As mutations are rare but methylation is common...
