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Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing

If and how proteasomes catalyze not only peptide hydrolysis but also peptide splicing is an open question that has divided the scientific community. The debate has so far been based on immunopeptidomics, in vi...

Wai Tuck Soh, Hanna P. Roetschke, John A. Cormican, Bei Fang Teo… in Nature Communications (2024)