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Article
Roles of Baseline Intrinsic Capacity and its Subdomains on the Overall Efficacy of Multidomain Intervention in Promoting Healthy Aging among Community-Dwelling Older Adults: Analysis from a Nationwide Cluster-Randomized Controlled Trial
Impaired intrinsic capacity (IC), which affects approximately 90% of older adults, is associated with a significantly heightened risk of frailty and cognitive decline. Existing evidence suggests that multidoma...
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Article
Dose-Responsive Impacts of Social Frailty on Intrinsic Capacity and Healthy Aging among Community-Dwelling Middle-aged and Older Adults: Stronger Roles of Social Determinants over Biomarkers
The intricate relationship between social determinants, e.g., social frailty, biomarkers and healthy aging remains largely unexplored, despite the potential for social frailty to impact both intrinsic capacity...
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Article
Disentangling Mortality Associations: An In-depth Comparative Study of Possible Sarcopenia versus Sarcopenia of AWGS 2019
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Article
Cardiovascular Disease Risk Burden, Cognitive Impairments and Incident Dementia among Community-Dwelling Middle-Aged and Older Adults: An 8-Year Longitudinal Follow-up Study
To evaluate the associations between cardiovascular disease (CVD) risk burden (estimated by the World Health Organization (WHO) algorithm) and cognitive impairments (e.g., incident dementia, global and domain-...
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Article
Age- and Sex-Different Associations between Cognitive Performance and Inflammatory Biomarkers in Community Dwelling Older Adults: towards Precision Preventive Strategies
Studies have demonstrated associations between inflammatory biomarkers and cognitive function in people with dementia or stroke, but little is known regarding these associations in healthy middle-aged and olde...
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Article
Clinical Efficacy of Multidomain Interventions among Multimorbid Older People Stratified by the Status of Physio-Cognitive Declines: A Secondary Analysis from the Randomized Controlled Trial for Healthy Aging
To investigate the clinical efficacy of integrated multidomain intervention among community-living older adults with multimorbidity and physio-cognitive decline syndrome (PCDS).
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Article
Physio-Cognitive Decline Syndrome as the Phenotype and Treatment Target of Unhealthy Aging
In this era of unprecedented longevity, healthy aging is an important public health priority. Avoiding or shortening the period of disability or dementia before death is critical to achieving the defining obje...
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Article
Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate (HMB) Improves Nutrition, Physical Performance and Ameliorates Intramuscular Adiposity in Pre-Frail Older Adults: A Randomized Controlled Trial
Supplementation of high protein oral nutrition shakes supplemented with β-hydroxy-β-methylbutyrate (HP-HMB) has been shown to improve muscle mass, muscle strength, and physical performance in older adults, but...
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Article
Removal of Pharmaceutical Contaminants from Aqueous Medium: A State-of-the-Art Review Based on Paracetamol
The usage of pharmaceutical products is becoming increasingly extensive because of the emerging ailments. Analgesic and antipyretic drugs are ranked the most used drugs worldwide. Unused or expired analgesic a...
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Article
Predicting New-Onset Diabetes Mellitus by Component Combinations of Premorbid Metabolic Syndrome among Older Adults in Taiwan
Metabolic syndrome (MS) was conceptualized to identify people at risk for cardiovascular disease and type 2 diabetes; however, the epidemiology of MS and its combinations of components in older adults remains ...
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Article
Effect of Body Weight, Waist Circumference and Their Changes on Mortality: A 10-Year Population-Based Study
To investigate the effect of body weight, waist circumference and their changes on all-cause and cardiovascular mortality.
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Article
Robustness of dynamic magnetism in the triangle-based antiferromagnets Ba3Ru1−xIr x Ti2O9 (x = 0.5 and 0.8)
We report on the spin dynamics of the strong spin-orbit coupled antiferromagnets Ba3Ru1−xIr x Ti2O9 (x = 0.5 and 0.8), which comprise a mixture of edge- and corner-sharing triang...
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Article
Association of new-onset diabetes mellitus in older people and mortality in Taiwan: A 10-year nationwide population-based study
Older patients with diabetes mellitus are at a higher risk of develo** diabetic macro- and micro-vascular complications and cardiovascular diseases than younger diabetes mellitus patients. However, older dia...
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Article
Foxp3 is a key downstream regulator of p53-mediated cellular senescence
The downstream events and target genes of p53 in the process of senescence are not fully understood. Here, we report a novel function of the forkhead transcription factor Foxp3, which is a key player in mediat...
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Article
Fundus autofluorescence imaging patterns in central serous chorioretinopathy according to chronicity
To investigate the time-period characteristics associated with morphologic changes in central serous chorioretinopathy (CSC) using fundus autofluorescence (FAF).
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Article
Generic piperacillin/tazobactam is not associated with galactomannan false-positivity in adult patients with cancer: a case–control study
Recent products of piperacillin/tazobactam (PTZ) from the original manufacturer, previously considered a major cause of galactomannan (GM) false-positivity, are reported not to be related to it. However, data ...
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Article
Risk factors for cytomegalovirus gastrointestinal diseases in adult patients with cancer
Cytomegalovirus (CMV) gastrointestinal (GI) disease has been noticed frequently in cancer patients, causing abdominal pain, diarrhea, and GI bleeding. However, little is known about its actual incidence, clini...
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Article
Oxygen pressure dependence of Ti-doped In-Zn-O thin film transistors
Indium-Titanium-Zinc-Oxide (ITZO) thin film transistors (TFTs) with bottom gate structure were fabricated at various oxygen pressures by pulsed laser deposition (PLD). All the ITZO thin films are amorphous and...
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Article
Open AccessLigand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1
Peroxisome proliferator-activated receptors (PPARs) inhibit lipopolysaccharide (LPS)-primed release of high mobility group box 1 (HMGB1), a late proinflammatory mediator, but the underlying molecular mechanism...
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Article
Ischemic diabetic retinopathy as a possible prognostic factor for chronic kidney disease progression
To assess the value of diabetic retinopathy (DR) severity as a possible predictive prognostic factor for the progression of chronic kidney disease (CKD).
