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  1. No Access

    Article

    Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies

    Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activi...

    Y Cao, J W Marks, Z Liu, L H Cheung, W N Hittelman, M G Rosenblum in Oncogene (2014)

  2. No Access

    Chapter and Conference Paper

    Epidermal Growth Factor Receptor Expression in Head and Neck Tumorigenesis and Saturation of EGFR with Monoclonal Antibody RG83852

    The survival rates of patients with head and neck squamous cell carcinoma have improved only marginally over the past two decades despite some improvements in diagnosis and therapeutic modalities. Chemoprevent...

    D. M. Shin, R. Perez-Soler, W. N. Hittelman… in EGF Receptor in Tumor Growth and Progressi… (1997)

  3. No Access

    Chapter

    The Use of Premature Chromosome Condensation and Chromosome Painting to Understand Chromosome Exchange Formation

    Based on studies where interphase cells are treated with DNA damaging agents and then analyzed in mitosis for chromosome aberrations, two general models for aberration production have been proposed (Evans 1962...

    W. N. Hittelman, D. Wlodek, V. Gregoire, T. K. Pandita in Chromosomal Alterations (1994)

  4. No Access

    Chapter and Conference Paper

    Probing the Pathophysiology of Leukemic Response by Premature Chromosome Condensation

    The myeloid leukemic process is generally thought to involve a series of genetic changes in a hematopoietic progenitor or stem cell that results in a dysregulation of proliferation and maturation of myeloid el...

    W. N. Hittelman, R. Vyas in Acute Leukemias (1992)

  5. No Access

    Chapter

    Tumorigenesis and Tumor Response: View from the (Prematurely Condensed) Chromosome

    Chromosome changes have long been known to be associated with the process of tumor development (Boveri 1914). For example, individuals with chromosome breakage syndromes such as ataxia telangiectasia and xerod...

    W. N. Hittelman, N. Cheong, H. Y. Sohn, J. S. Lee, J.-D. Tigaud… in Chromosomal Aberrations (1990)

  6. No Access

    Chapter

    Nucleic Acid Cytometry, Interphase Chromosomes and Nucleolar Antigen in the Detection of Residual Leukemia in Morphologic Remission

    Currently available combination chemotherapy for acute leukemia in adults produces complete hematologic normalization, commonly referred to as complete remission, in approximately 65% of patients (1,2,3). Alth...

    B. Barlogie, W. N. Hittelman, F. M. Davis… in Minimal Residual Disease in Acute Leukemia (1984)

  7. No Access

    Article

    Relevance of density, size and DNA content of tumour cells to the lung colony assay

    Mouse fibrosarcoma tumours were dissociated and divided into subpopulations of viable cells by centrifugation in linear density gradients of Renografin. Two of these subpopulations, designated Band 2 and Band ...

    D J Grdina, W N Hittelman, R A White, M L Meistrich in British Journal of Cancer (1977)

  8. No Access

    Article

    Sister chromatid differential staining pattern in prematurely condensed chromosomes

    Application of sister chromatid differential (SCD) procedure on G1, S and G2 prematurely condensed chromosomes (PCC) of cells in the second and third cycle of DNA replication in medium containing BrdU reveals dif...

    Yun-Fai Lau, W. N. Hittelman, F. E. Arrighi in Experientia (1976)