6 Result(s)
within
W Evan Johnson
Cancer Research
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Article
The oral microbiome in relation to pancreatic cancer risk in African Americans
African Americans have the highest pancreatic cancer incidence of any racial/ethnic group in the United States. The oral microbiome was associated with pancreatic cancer risk in a recent study, but no such stu...
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Article
Open AccessNovel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies
Metastatic breast cancer is a deadly disease with a low 5-year survival rate. Tracking metastatic spread in living patients is difficult and thus poorly understood.
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Article
Open AccessPathway activity profiling of growth factor receptor network and stemness pathways differentiates metaplastic breast cancer histological subtypes
Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for next-generation sequencing. We customized a gene expr...
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Article
Open AccessActivity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes
The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components,...
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Article
Open AccessLow concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing
To facilitate the clinical implementation of genomic medicine by next-generation sequencing, it will be critically important to obtain accurate and consistent variant calls on personal genomes. Multiple softwa...
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Article
Tackling the widespread and critical impact of batch effects in high-throughput data
Batch effects can lead to incorrect biological conclusions but are not widely considered. The authors show that batch effects are relevant to a range of high-throughput 'omics' data sets and are crucial to add...
