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  1. No Access

    Article

    Epigenetic effects of low-level sodium arsenite exposure on human liver HepaRG cells

    Chronic exposure to inorganic arsenic is associated with a variety of adverse health effects, including lung, bladder, kidney, and liver cancer. Several mechanisms have been proposed for arsenic-induced tumori...

    Volodymyr P. Tryndyak, Barbara Borowa-Mazgaj, Colleen R. Steward… in Archives of Toxicology (2020)

  2. Article

    Open Access

    Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

    Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and Western countries. In humans, genetic factors greatly influence individu...

    Volodymyr P. Tryndyak, Tao Han, James C. Fuscoe, Sharon A. Ross… in BMC Genomics (2016)

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  3. No Access

    Article

    An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

    Epigenetic biomarkers are emerging as determinants of breast cancer prognosis. Breast cancer cells display unique alterations in major cellular metabolic pathways and it is becoming widely recognized that enzy...

    Natalie E. Simpson, Volodymyr P. Tryndyak… in Breast Cancer Research and Treatment (2012)

  4. No Access

    Article

    Role of ferritin alterations in human breast cancer cells

    Breast cancer is the most common malignancy in women. Successful treatment of breast cancer relies on a better understanding of the molecular mechanisms involved in breast cancer initiation and progression. Re...

    Svitlana I. Shpyleva, Volodymyr P. Tryndyak… in Breast Cancer Research and Treatment (2011)