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    Article

    Metabolites of synthetic cannabinoids in hair—proof of consumption or false friends for interpretation?

    The detection of drug metabolites in hair is widely accepted as a proof for systemic uptake of the drug, unless the metabolites can be formed as artefacts. However, regarding synthetic cannabinoids, not much i...

    Florian Franz, Verena Angerer… in Analytical and Bioanalytical Chemistry (2016)

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    Article

    Studies on the metabolism and toxicological detection of the new psychoactive designer drug 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe) in human and rat urine using GC-MS, LC-MSn, and LC-HR-MS/MS

    25I-NBOMe, a new psychoactive substance, is a potent 5-HT2A receptor agonist with strong hallucinogenic potential. Recently, it was involved in several fatal and non-fatal intoxication cases. The aim of the prese...

    Achim T. Caspar, Andreas G. Helfer… in Analytical and Bioanalytical Chemistry (2015)

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    Article

    A fast and inexpensive procedure for the isolation of synthetic cannabinoids from ‘Spice’ products using a flash chromatography system

    In the age of the Internet, the variety of drugs offered online is constantly increasing, and new drugs emerge every month. One group of drugs showing such an enormous increase is that of synthetic cannabinoid...

    Bjoern Moosmann, Stefan Kneisel, Ariane Wohlfarth… in Analytical and Bioanalytical Chemistry (2013)

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    Article

    LC/ESI-MS/MS method for quantification of 28 synthetic cannabinoids in neat oral fluid and its application to preliminary studies on their detection windows

    Serum and urine samples are commonly used for the analysis of synthetic cannabinoids in biofluids; however, their utilization as analytical matrices for drug abstinence control features some substantial drawba...

    Stefan Kneisel, Michael Speck, Bjoern Moosmann… in Analytical and Bioanalytical Chemistry (2013)

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    Article

    Sensitive quantification of clozapine and its main metabolites norclozapine and clozapine-N-oxide in serum and urine using LC-MS/MS after simple liquid–liquid extraction work-up

    An LC-MS/MS method for the determination of the atypic neuroleptic clozapine and its two main metabolites norclozapine and clozapine-N-oxide has been developed and validated for serum and urine. After addition of...

    Ariane Wohlfarth, Nicole Toepfner… in Analytical and Bioanalytical Chemistry (2011)