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Structural basis of histone H2A–H2B recognition by the essential chaperone FACT

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  1. Article

    Open Access

    Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq

    The RNA-chaperone Hfq catalyses the annealing of bacterial small RNAs (sRNAs) with target mRNAs to regulate gene expression in response to environmental stimuli. Hfq acts on a diverse set of sRNA-mRNA pairs us...

    Eike C. Schulz, Markus Seiler, Cecilia Zuliani, Franka Voigt in Scientific Reports (2017)

  2. Article

    Open Access

    A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT

    Bromodomains are critical components of many chromatin modifying/remodelling proteins and are emerging therapeutic targets, yet how they interact with nucleosomes, rather than acetylated peptides, remains uncl...

    Thomas C. R. Miller, Bernd Simon, Vladimir Rybin, Helga Grötsch in Nature Communications (2016)

  3. Article

    A family of macrodomain proteins reverses cellular mono-ADP-ribosylation

    ADP-ribosylation catalyzed by PARPs and sirtuins is an important post-translation modification. Macrodomain proteins MacroD1 and D2 are now shown to preferentially bind mono-ADP-ribosylated proteins and to act...

    Gytis Jankevicius, Markus Hassler, Barbara Golia in Nature Structural & Molecular Biology (2013)

  4. Article

    Endosome dynamics regulated by a Rho protein

    Vesicular transport is a dynamic process that requires coordinated interactions between membrane and cytoskeleton. The mechanisms and molecules integrating these interactions are unclear. A Rho protein, RhoD, ...

    Carol Murphy, Rainer Saffrich, Maika Grummt, Hélèna Gournier, Vladimir Rybin in Nature (1996)