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  1. No Access

    Article

    New Trends in Financing Biotechnology

    Patterns of biotechnology financing have undergone subtle shifts in recent months, and the shifts are an indication that the industry is moving from childhood into adolescence. Once the central source of suppo...

    Vivian Lee, John Gurnsey, Arthur Klausner in Bio/Technology (1983)

  2. Article

    French Science Salutes Biotechnology

    Vivian Lee in Bio/Technology (1983)

  3. No Access

    Article

    Creating New Enzymes With Chemistry

    Vivian Lee in Bio/Technology (1984)

  4. No Access

    Article

    NK cell activation and tumor infiltration are involved in the antitumor mechanism of Virulizin

    Previous studies have demonstrated antitumor efficacy of Virulizin in several human tumor xenograft models and a critical role for macrophages in the antitumor mechanism of Virulizin. Although there is growing...

    Ming Yu Cao, Yoon Lee, Ning** Feng, Hui Li, Caigan Du in Cancer Immunology, Immunotherapy (2005)

  5. Article

    Open Access

    An evaluation of GO annotation retrieval for BioCreAtIvE and GOA

    The Gene Ontology Annotation (GOA) database http://www.ebi.ac.uk/GOA aims to provide high-quality supplementary GO annotation to proteins in the UniProt Know...

    Evelyn B Camon, Daniel G Barrell, Emily C Dimmer, Vivian Lee in BMC Bioinformatics (2005)

  6. No Access

    Article

    Virulizin, a novel immunotherapy agent, activates NK cells through induction of IL-12 expression in macrophages

    Virulizin, a novel biological response modifier, has demonstrated significant antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cance...

    Hui Li, Ming Y. Cao, Yoon Lee, Vivian Lee in Cancer Immunology, Immunotherapy (2005)

  7. Article

    Open Access

    GOAnnotator: linking protein GO annotations to evidence text

    Annotation of proteins with gene ontology (GO) terms is ongoing work and a complex task. Manual GO annotation is precise and precious, but it is time-consuming. Therefore, instead of curated annotations most o...

    Francisco M Couto, Mário J Silva, Vivian Lee in Journal of Biomedical Discovery and Collab… (2006)

  8. No Access

    Article

    Reproductible production of a PEGylated dual-acting peptide for diabetes

    A pEGylated glucagon-like peptide-1 (GLP-1) agonist and glucagon antagonist hybrid peptide was engineered as a potential treatment for type 2 diabetes. To support preclinical development of this PEGylated dual...

    Irene Tom, Vivian Lee, Michael Dumas, Melanie Madanat, Jun Ouyang in The AAPS Journal (2007)

  9. Article

    Open Access

    Assessment of disease named entity recognition on a corpus of annotated sentences

    In recent years, the recognition of semantic types from the biomedical scientific literature has been focused on named entities like protein and gene names (PGNs) and gene ontology terms (GO terms). Other sema...

    Antonio Jimeno, Ernesto Jimenez-Ruiz, Vivian Lee, Sylvain Gaudan in BMC Bioinformatics (2008)

  10. No Access

    Article

    Virulizin® induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors

    Virulizin® has demonstrated strong antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cancer and prostate cancer. Our previous studies ha...

    Tania Benatar, Ming Y. Cao, Yoon Lee, Hui Li in Cancer Immunology, Immunotherapy (2008)

  11. Article

    Open Access

    Risk factors for human infection with West Nile Virus in Connecticut: a multi-year analysis

    The optimal method for early prediction of human West Nile virus (WNV) infection risk remains controversial. We analyzed the predictive utility of risk factor data for human WNV over a six-year period in Conne...

    Ann Liu, Vivian Lee, Deron Galusha in International Journal of Health Geographics (2009)

  12. No Access

    Article

    IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo

    Interleukin-17E (IL-17E) belongs to a novel family of cytokines that possess significant homology to IL-17. IL-17E has potent inflammatory effects in vitro and in vivo. Overexpression of IL-17E in mice results...

    Tania Benatar, Ming Y. Cao, Yoon Lee, Jeff Lightfoot in Cancer Immunology, Immunotherapy (2010)

  13. Article

    Open Access

    The BioLexicon: a large-scale terminological resource for biomedical text mining

    Due to the rapidly expanding body of biomedical literature, biologists require increasingly sophisticated and efficient systems to help them to search for relevant information. Such systems should account for ...

    Paul Thompson, John McNaught, Simonetta Montemagni in BMC Bioinformatics (2011)

  14. No Access

    Chapter and Conference Paper

    Applying Semantic Technologies to Public Sector: A Case Study in Fraud Detection

    Fraudulent claims cost both the public and private sectors an enormous amount of money each year. The existence of data silos is considered one of the main barriers to cross-region, cross-department, and cross...

    Bo Hu, Nuno Carvalho, Loredana Laera, Vivian Lee in Semantic Technology (2013)

  15. No Access

    Article

    Thermal environment shapes cuticle melanism and melanin-based immunity in the ground cricket Allonemobius socius

    The thermal melanin hypothesis posits that ectothermic individuals of larger size or from colder environments exhibit darker cuticles due to melanin’s efficacy in absorbing solar radiation. However, melanin is...

    Kenneth M. Fedorka, Vivian Lee, Wade E. Winterhalter in Evolutionary Ecology (2013)

  16. Chapter and Conference Paper

    Exploiting Linked Data in Financial Engineering

    In this paper, we report on a recent initiative that exploiting Linked Data for financial data integration. Financial data present high heterogeneity. Linked Data helps to reveal the true data semantics and “h...

    Vivian Lee, Masatomo Goto, Bo Hu, Aisha Naseer in Service Science and Knowledge Innovation (2014)

  17. No Access

    Protocol

    In Vitro Approaches to Assessing the Toxicity of Quantum Dots

    Advances in nanotechnology have produced a new class of fluorescent nanoparticles known as quantum dots (Qdots). Compared with organic dyes and fluorescent proteins, Qdots offer several unique advantages in te...

    Ryan S. McMahan, Vivian Lee, William C. Parks in Quantum Dots: Applications in Biology (2014)

  18. Article

    Open Access

    The emergency to home project: impact of an emergency department care coordinator on hospital admission and emergency department utilization among seniors

    Seniors comprise 14% to 21% of all emergency department (ED) visits, yet are disproportionately larger users of ED and inpatient resources. ED care coordinators (EDCCs) target seniors at risk for functional de...

    Christopher Matthew Bond in International Journal of Emergency Medicine (2014)

  19. No Access

    Chapter and Conference Paper

    Patient Lifecycle Management: An Approach for Clinical Processes

    Clinical processes can be described, inside the Biomedical scope, like a systematic guideline to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. In ...

    Alberto Salido López, Carmelo Del Valle in Bioinformatics and Biomedical Engineering (2015)

  20. No Access

    Article

    Brief Report: Infants Develo** with ASD Show a Unique Developmental Pattern of Facial Feature Scanning

    Infants are interested in eyes, but look preferentially at mouths toward the end of the first year, when word learning begins. Language delays are characteristic of children develo** with autism spectrum dis...

    M. D. Rutherford, Jennifer A. Walsh in Journal of Autism and Developmental Disord… (2015)

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