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Article
Open AccessImpact of Bacteria Types on the Clinical Outcomes of Spontaneous Bacterial Peritonitis
Cirrhotic patients presenting with spontaneous bacterial peritonitis (SBP) have elevated risk of short-term mortality. While high Model for End-Stage Liver Disease-Sodium score (MELD-Na) and ascites culture yi...
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Article
Patient perspectives on window of opportunity clinical trials in early-stage breast cancer
Window of opportunity trials (WOT) are increasingly common in oncology research. In WOT participants receive a drug between diagnosis and anti-cancer treatment, usually for the purpose of investigating that dr...
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Article
The WISDOM study: a new approach to screening can and should be tested
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Article
Open AccessDeep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study
To determine if mammographic features from deep learning networks can be applied in breast cancer to identify groups at interval invasive cancer risk due to masking beyond using traditional breast density meas...
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Article
IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo
Interleukin-17E (IL-17E) belongs to a novel family of cytokines that possess significant homology to IL-17. IL-17E has potent inflammatory effects in vitro and in vivo. Overexpression of IL-17E in mice results...
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Article
Virulizin® induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors
Virulizin® has demonstrated strong antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cancer and prostate cancer. Our previous studies ha...
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Article
Virulizin, a novel immunotherapy agent, activates NK cells through induction of IL-12 expression in macrophages
Virulizin, a novel biological response modifier, has demonstrated significant antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cance...
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Article
NK cell activation and tumor infiltration are involved in the antitumor mechanism of Virulizin
Previous studies have demonstrated antitumor efficacy of Virulizin in several human tumor xenograft models and a critical role for macrophages in the antitumor mechanism of Virulizin. Although there is growing...
