-
Article
Open AccessCharacterizing attitudes related to future child-bearing in young women diagnosed with early-stage breast cancer
This study characterizes attitudes and decision-making around the desire for future children in young women newly diagnosed with early-stage breast cancer and assesses how clinical factors and perceived risk m...
-
Article
Open AccessCirculating tumor cells in early lobular versus ductal breast cancer and their associations with prognosis
This is a secondary data analysis of the TIPPING study, which included 1,121 patients with stage I-III breast cancer who had enumeration of CTCs (by either CellSearch or immunomagnetic enrichment and flow cyto...
-
Article
Open AccessNovel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
Despite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory therapies have met with mixed results, likely due in part to biological...
-
Article
Open AccessThe impact of histologic subtype on primary site surgery in the management of metastatic lobular versus ductal breast cancer: a population based study from the National Cancer Database (NCDB)
Primary site surgery for metastatic breast cancer improves local control but does not impact overall survival. Whether histologic subtype influences patient selection for surgery is unknown. Given differences ...
-
Article
Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification
In the 2022 fifth edition of the WHO Classification of Endocrine Tumours and of Central Nervous System Tumours, pituitary adenomas are reclassified as neuroendocrine tumours (NETs). This change confers an onco...
-
Article
Open AccessRadiomic tumor phenotypes augment molecular profiling in predicting recurrence free survival after breast neoadjuvant chemotherapy
Early changes in breast intratumor heterogeneity during neoadjuvant chemotherapy may reflect the tumor’s ability to adapt and evade treatment. We investigated the combination of precision medicine predictors o...
-
Article
Open AccessRAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
HER2 is a predictive biomarker for HER2-targeted therapeutics. For antibody–drug conjugates (ADCs; e.g., trastuzumab emtansine (T-DM1)), HER2 is utilized as a transport gate for cytotoxic agents into the cell....
-
Article
The WISDOM study: a new approach to screening can and should be tested
-
Article
Open AccessCirculating tumor DNA and magnetic resonance imaging to predict neoadjuvant chemotherapy response and recurrence risk
We investigated whether serial measurements of circulating tumor DNA (ctDNA) and functional tumor volume (FTV) by magnetic resonance imaging (MRI) can be combined to improve prediction of pathologic complete r...
-
Article
Open AccessCharacterizing the Tumor Immune Microenvironment with Tyramide-Based Multiplex Immunofluorescence
Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection of multiple markers with a nuclear counterstain on a single tissue section. Recent studies have demonstrated that mIF is becoming...
-
Article
Open AccessMechanism of action biomarkers predicting response to AKT inhibition in the I-SPY 2 breast cancer trial
The AKT inhibitor MK2206 (M) was evaluated in I-SPY 2 and graduated in the HER2+, HR−, and HR− HER2+ signatures. We hypothesized that AKT signaling axis proteins/genes may specifically predict response to M an...
-
Chapter
Pragmatic Trials and Approaches to Transforming Care
When considering medical interventions and tools for learning and advancing a field, one perspective is to test a drug, device, or intervention in a highly controlled setting, where inclusion and exclusion cri...
-
Article
A response to “Personalised medicine and population health: breast and ovarian cancer”
-
Article
Open AccessExploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis
Radiomics is an emerging technology for imaging biomarker discovery and disease-specific personalized treatment management. This paper aims to determine the benefit of using multi-modality radiomics data from ...
-
Article
Open AccessDNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial
Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature. H...
-
Article
Comparison of residual cancer burden, American Joint Committee on Cancer staging and pathologic complete response in breast cancer after neoadjuvant chemotherapy: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)
Several pathologic staging systems characterize residual tumor in patients undergoing neoadjuvant chemotherapy for breast cancer. Pathologic complete response (pCR) is now accepted by the Food and Drug Adminis...
-
Article
Co-expression modules identified from published immune signatures reveal five distinct immune subtypes in breast cancer
There is a growing body of literature demonstrating that immune-related expression signatures predict breast cancer prognosis and chemo-/targeted-therapy responsiveness. However, it is unclear whether these si...
-
Article
Characterizing the immune microenvironment in high-risk ductal carcinoma in situ of the breast
The recent increase in the incidence of ductal carcinoma in situ (DCIS) has sparked debate over the classification and treatment of this disease. Although DCIS is considered a precursor lesion to invasive brea...
-
Article
Post Mastectomy Pain Syndrome Management
Post mastectomy pain syndrome is a chronic pain condition that occurs after surgical intervention. This problem has long been underrecognized, however it affects a large percentage of women following treatmen...
-
Article
Open AccessSerial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response
The molecular biology involving neoadjuvant chemotherapy (NAC) response is poorly understood. To elucidate the impact of NAC on the breast cancer transcriptome and its association with clinical outcome, we ana...
