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A self-transmissible plasmid from a hyperthermophile that facilitates genetic modification of diverse Archaea
Conjugative plasmids are self-transmissible mobile genetic elements that transfer DNA between host cells via type IV secretion systems (T4SS). While T4SS-mediated conjugation has been well-studied in bacteria,...
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Article
Open AccessA paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea
In Archaea and Eukaryotes, the synthesis of a universal tRNA modification, N6-threonyl-carbamoyl adenosine (t6A), is catalyzed by the KEOPS complex composed of Kae1, Bud32, Cgi121, and Pcc1. A fifth subunit, Gon7...
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Open AccessLife at high temperature observed in vitro upon laser heating of gold nanoparticles
Thermophiles are microorganisms that thrive at high temperature. Studying them can provide valuable information on how life has adapted to extreme conditions. However, high temperature conditions are difficult...
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Article
Open AccessExploring short k-mer profiles in cells and mobile elements from Archaea highlights the major influence of both the ecological niche and evolutionary history
K-mer-based methods have greatly advanced in recent years, largely driven by the realization of their biological significance and by the advent of next-generation sequencing. Their speed and their independence...
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The Tree of Life
The tree of life, representing the evolution and the relationships between all life-forms, has challenged scientists as soon as Darwin’s work became accepted. A fuel for imagination for a long time, it became ...
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Article
Plasmid vesicles mimicking virions
A newly described plasmid, which encodes proteins facilitating its packaging and cell-to-cell transfer via membrane vesicles, challenges the way we think about the delineation of viruses, plasmids and extracel...
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Article
Open AccessSingle nucleotide resolution RNA-seq uncovers new regulatory mechanisms in the opportunistic pathogen Streptococcus agalactiae
Streptococcus agalactiae, or Group B Streptococcus, is a leading cause of neonatal infections and an increasing cause of infections in adults with underlying diseases. In an effort to reconstru...
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Correction: Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Nature Communications 5: Article number:4544 (2014); Published 4 Aug 2014; Updated 28 Jan 2015 The original version of this Article contained an error in the spelling of a member of the DEVANI Consortium, Luci...
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Article
Open AccessStreptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North Amer...
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Article
Open AccessReductive evolution in Streptococcus agalactiaeand the emergence of a host adapted lineage
During host specialization, inactivation of genes whose function is no more required is favored by changes in selective constraints and evolutionary bottlenecks. The Gram positive bacteria Streptococcus agalactia...
