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Chapter
Local Delivery of Antibiotic and Antiseptic
Total knee arthroplasty (TKA) is considered one of the most cost-effective orthopedic surgical procedures with more than one million procedures performed every year. Periprosthetic joint infection (PJI) is a r...
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Article
Open AccessSurvivorship and clinical outcomes of proximal femoral replacement in non-neoplastic primary and revision total hip arthroplasty: a systematic review
Several studies have evaluated the survivorship and clinical outcomes of proximal femoral replacement (PFR) in complex primary and revision total hip arthroplasty with severe proximal femoral bone loss; howeve...
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Reference Work Entry In depth
Microiontophoresis and Related Methods
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Article
Chronic administration of Norwegian Ascophyllum nodosum phytocomplex inhibits high-fat-diet-induced obesity in male rats
Several biologically active compounds are present in seaweeds that show a wide range of biological properties, such as antibiotic, anti-inflammatory, antioxidant, cytotoxic, antitumour and anti-obesity activit...
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Article
5-HT2 receptors-mediated modulation of voltage-gated K+ channels and neurophysiopathological correlates
The activity of voltage-gated K+ channels (Kv) can be dynamically modulated by several events, including neurotransmitter stimulated biochemical cascades mediated by G protein-coupled receptors such as 5-HT2 rece...
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Book
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Protocol
In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration
Microdialysis cerebral technique has been widely employed in order to study neurotransmitter release. This technique presents numerous advantages such as it allows work with sample in vivo from freely moving a...
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Book
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Chapter
The 5-HT2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies
Several studies have focused on the role of serotonergic 5-HT2C receptors in the regulation of forebrain dopamine (DA) function and have highlighted their potential as a target for improved treatments of neuropsy...
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Book Series
Journal of Neural Transmission. Supplementa
Volume 70 / 2006 to Volume 73 / 2009
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Book
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Chapter and Conference Paper
Preferential Modulation of the GABAergic vs. Dopaminergic Function in the Substantia Nigra by 5-HT2C Receptor
Serotonin (5-HT) is intimately involved in the modulation of the basal ganglia circuitry and in its pathologies. The 5-HT pivotal role is supported by anatomical evidence demonstrating a large serotonergic inn...
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Chapter and Conference Paper
Nitric Oxide Modulation of the Dopaminergic Nigrostriatal System: Focus on Nicotine Action
Nitric oxide (NO) signalling plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophy...
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Chapter
Electrophysiological and Neurochemical Characterization of 7-Nitroindazole and Molsidomine Acute and Sub-Chronic Administration Effects in the Dopaminergic Nigrostrial System in Rats
Nitric oxide (NO) plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophysiological ...
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Chapter
In Vivo Microdialysis in Parkinson’s Research
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopamine (DA) neurons in the nigrostriatal system, which in turn produces profound ne...
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Chapter
Intake of Tomato-Enriched Diet Protects from 6-Hydroxydopamine-Induced Degeneration of Rat Nigral Dopaminergic Neurons
There is extensive evidence that oxidative damage of dopamine (DA)-containing neurons in the substantia nigra pars compacta (SNc) may contribute to the pathogenesis of Parkinson’s disease (PD). We evaluated the p...
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Article
Acute administration of amitriptyline and mianserin increases dopamine release in the rat nucleus accumbens: possible involvement of serotonin2C receptors
Previous studies of conventional tricyclic and non-tricyclic antidepressants have suggested that a number of these drugs display considerable pharmacological activity at 5-HT2C receptors in the brain. There is e...