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Article
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity
Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapies. Here, we report the identification and characterization of hexahydr...
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Article
Open AccessEsterase mutation is a mechanism of resistance to antimalarial compounds
Pepstatin is a potent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity. Activity of pepstatin against cultured Plasmodium falciparum is highly variable depending on t...
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Article
Open AccessA broad analysis of resistance development in the malaria parasite
Microbial resistance to chemotherapy has caused countless deaths where malaria is endemic. Chemotherapy may fail either due to pre-existing resistance or evolution of drug-resistant parasites. Here we use a di...
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Article
Open AccessIdentification of pathogen genomic variants through an integrated pipeline
Whole-genome sequencing represents a powerful experimental tool for pathogen research. We present methods for the analysis of small eukaryotic genomes, including a streamlined system (called Platypus) for find...
