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Open AccessThe epicardial delivery of cardiosphere derived cells or their extracellular vesicles is safe but of limited value in experimental infarction
The epicardial administration of therapeutics via the pericardial sac offers an attractive route, since it is minimally invasive and carries no risks of coronary embolization. The aim of this study was to asse...
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Author Correction: The Intrapericardial Delivery of Extracellular Vesicles from Cardiosphere-Derived Cells Stimulates M2 Polarization during the Acute Phase of Porcine Myocardial Infarction
The original version of this article unfortunately contained a mistake. In the author group, the correct family name of Dr. Rebeca is “Blázquez” and the correct family name of Dr. Francisco Miguel is “Sánchez-...
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Article
Open AccessThe Intrapericardial Delivery of Extracellular Vesicles from Cardiosphere-Derived Cells Stimulates M2 Polarization during the Acute Phase of Porcine Myocardial Infarction
Acute myocardial infarction triggers a strong inflammatory response in the affected cardiac tissue. New therapeutic tools based on stem cell therapy may modulate the unbalanced inflammation in the damaged card...
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Open AccessMicroencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model
Insulin-like growth factor-1 (IGF-1) has demonstrated beneficial effects after myocardial infarction (MI). Microencapsulation of IGF-1 could potentially improve results. We aimed to test the effect of an intra...
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Open AccessCIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions
Despite many cardioprotective interventions have shown to protect the heart against ischemia/reperfusion injury in the experimental setting, only few of them have succeeded in translating their findings into p...
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Open AccessIdentification of very early inflammatory markers in a porcine myocardial infarction model
Acute myocardial infarction (AMI) is one of the most deleterious conditions leading to cardiovascular diseases and mortality. The importance of an early and accurate diagnosis assures immediate medical treatme...
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Open AccessCombined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model
Insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) are among the most promising growth factors for promoting cardiorepair. Here, we evaluated the combination of cell- and gene-based therap...
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Prostatic Artery Embolization (PAE) for Symptomatic Benign Prostatic Hyperplasia (BPH): Part 2, Insights into the Technical Rationale
Rationale of prostatic artery embolization (PAE) in the treatment of symptomatic benign prostatic hyperplasia is conventionally believed to include two parts: shrinkage of the enlarged prostate gland as a resu...
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Prostatic Artery Embolization (PAE) for Symptomatic Benign Prostatic Hyperplasia (BPH): Part 1, Pathological Background and Clinical Implications
Pathological features of benign prostatic hyperplasia (BPH) dictate various responses to prostatic artery embolization (PAE). Typically, BPH originates in the transition zone and periurethral region, where sho...
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Open AccessComparison of two preclinical myocardial infarct models: coronary coil deployment versus surgical ligation
Despite recent advances, myocardial infarction (MI) remains the leading cause of death worldwide. Pre-clinical animal models that closely mimic human MI are pivotal for a quick translation of research and swin...
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Evaluation of the Effects of Temporary Covered Nitinol Stent Placement in the Prostatic Urethra: Short-Term Study in the Canine Model
To evaluate the effect of temporary stent placement on the canine prostatic urethra.
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Fine-needle percutaneous transhepatic parenchymal portal venography by using carbon dioxide: a pilot study in pigs
Our purpose was to evaluate the feasibility and safety of carbon dioxide (CO2) in fine-needle percutaneous transhepatic parenchymal portal venography and its potential clinical applications. Three Belgian landra...
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End-to-end Anastomosis in Growing Vessels Using a Novel Suturing Technique: VCS Metallic Staples
For pediatric transplants, a suturing technique is needed that allows the vessel to grow along with better healing of the anastomosis, through eliminating exogenous and thrombogenic material in the intimal sid...