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Article
Open AccessWeight loss moderately affects the mixed meal challenge response of the plasma metabolome and transcriptome of peripheral blood mononuclear cells in abdominally obese subjects
The response to dietary challenges has been proposed as a more accurate measure of metabolic health than static measurements performed in the fasted state. This has prompted many groups to explore the potentia...
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Automated Annotation of Microbial and Human Flavonoid-Derived Metabolites
Flavonoids are a class of natural compounds essentially produced by plants that are part of animal and human diets and have assumed health-promoting benefits. Upon human consumption, these flavonoids are to a ...
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Article
Automated quantum mechanical total line shape fitting model for quantitative NMR-based profiling of human serum metabolites
An automated quantum mechanical total line shape (QMTLS) fitting model was implemented for quantitative nuclear magnetic resonance (NMR)-based profiling of 42 metabolites in ultrafiltrated human serum samples....
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Article
Open AccessAccurate mass error correction in liquid chromatography time-of-flight mass spectrometry based metabolomics
Compound identification and annotation in (untargeted) metabolomics experiments based on accurate mass require the highest possible accuracy of the mass determination. Experimental LC/TOF-MS platforms equipped...