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Article
Heat shock factor 1 in brain tumors: a link with transient receptor potential channels TRPV1 and TRPA1
Novel data report a “cross-talk” between Heat-Shock Factor 1 (HSF1) and the transient receptor potential vanilloid 1 cation channel (TRPV1) located in the cell membrane, introducing these channels as possible ...
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Article
Transient receptor potential vanilloid (TRPV) channel expression in meningiomas: prognostic and predictive significance
The TRPV1–4 members of TRPV cation channel subfamily are mainly regarded as polymodal receptors that may be activated by diverse changes in cellular microenvironment and endogenous and exogenous agents. Abnorm...
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Article
Occipital lobe gumma: a case report and review of the literature
Syphilis has plagued humanity for thousands of years. Despite the measures of precaution against its transmission and the advancement of modern pharmacology, late-stage phenomena like intracerebral gumma are n...
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Article
Open AccessSuppurative necrotizing granulomatous lymphadenitis in adult-onset Still’s disease: a case report
Lymphadenopathy is found in about 65% of patients with adult-onset Still’s disease and is histologically characterized by an intense, paracortical immunoblastic hyperplasia. Adult-onset Still’s disease has not...
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Article
Prognostic value of novel biomarkers in astrocytic brain tumors: nuclear receptor co-regulators AIB1, TIF2, and PELP1 are associated with high tumor grade and worse patient prognosis
Estrogen receptors alpha (ERα) and beta (ERβ) and their co-regulatory proteins are key components of complex signaling networks that specifically regulate the growth and development of various tissues and tumo...
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Article
Open AccessHigh expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology
Bcl-2 promotes cell survival by inhibiting adapters needed for the activation and cleavage of caspases thus blocking the proteolytic cascade that ultimately dismantles the cell. Bcl-2 has been investigated as ...
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Article
Apoptotic mechanisms within the retina in Staphylococcus epidermidis experimental endophthalmitis
To investigate the potential involvement of apoptosis and its regulators Bcl-2, Bax, and Fas within the retina in Staphylococcus epidermidis experimental endophthalmitis.
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Bone Anatomy, Physiology and Function
Bone metastases depend on reciprocal interactions between malignant cells and bones that will determine the homing and growth of malignant cells in the bone microenvironment. Additionally, the final step of bo...
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Article
Mediastinal rhabdomyoma: case report and review of the literature
Rhabdomyomas are benign tumors in which at least some cells are differentiated as skeletal muscle cells with cytoplasmic cross-striations. Extracardiac adult rhabdomyoma is an extremely uncommon benign neoplas...
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Article
Case report: Leiomyosarcoma of the renal pelvis
We present a new case of leiomyosarcoma, a very rare clinical entity, arising from the renal pelvis. The primary diagnosis, based on asymptomatic gross hematuria and imaging findings, was tumor of the left kid...
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Article
The Potential Role of TGFβ1, TGFβ2 and TGFβ3 Protein Expression in Colorectal Carcinomas
This study investigates the expression of tumor growth factors TGFβ1, TGFβ2 and TGFβ3 in tissue material from patients with colorectal carcinoma and evaluates their correlation with known prognostic markers an...
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Article
S-100 protein-positive dendritic cells and CD34-positive dendritic interstitial cells in palatine tonsils
Dendritic cells (DCs) are effective antigen-presenting cells and have been shown to mature from precursor CD34-positive stromal cells (dendritic interstitial cells, DICs) or monocytes. To gain insight into th...
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Article
CASE REPORT: Neuromuscular and Vascular Hamartoma of the Small Bowel
