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Article
Open AccessMulti-organ denervation: a novel approach to combat cardiometabolic disease
Cardiometabolic disorders are associated with a substantial loss in quality of life and pose a large burden on healthcare systems worldwide. Overactivation of the sympathetic nervous system has been shown to b...
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Article
Open AccessTargeting Features of the Metabolic Syndrome Through Sympatholytic Effects of SGLT2 Inhibition
The moderate glucose-lowering effect of sodium glucose co-transporter 2 (SGLT2) inhibitors is unlikely to explain SGLT2 inhibitor-mediated beneficial outcomes, and unravelling the underlying mechanisms is a hi...
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Article
Open AccessCombined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model
Cardiovascular and metabolic regulation is governed by neurohumoral signalling in relevant organs such as kidney, liver, pancreas, duodenum, adipose tissue, and skeletal muscle. Combined targeting of relevant ...
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Article
Open AccessCorrection to: Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice)
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessRetinal capillary rarefaction is associated with arterial and kidney damage in hypertension
Microvascular disease and rarefaction are key pathological hallmarks of hypertension. The retina uniquely allows direct, non-invasive investigation of the microvasculature. Recently developed optical coherence...
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Article
New Molecules for Treating Resistant Hypertension: a Clinical Perspective
To review the findings of trials evaluating pharmacological treatment approaches for hypertension in general, and resistant hypertension (RH) in particular, and propose future research and clinical directions.
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Article
Open AccessMaternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice)
Epidemiological studies have identified strong relationships between maternal obesity and offspring respiratory dysfunction; however, the causal direction is not known. We tested whether maternal obesity alter...
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Article
Autonomic Regulation of Glucose Homeostasis: a Specific Role for Sympathetic Nervous System Activation
Cardiometabolic disorders such as obesity, metabolic syndrome and diabetes are increasingly common and associated with adverse cardiovascular outcomes. The mechanisms driving these developments are incompletel...
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Article
Open AccessIsoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet
Dietary fibre positively influences gut microbiome composition, enhancing the metabolism of dietary flavonoids to produce bioactive metabolites. These synergistic activities facilitate the beneficial effects o...
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Overcoming Insulin Resistance with Ciliary Neurotrophic Factor
The incidence of obesity and related co-morbidities such as insulin resistance, dyslipidemia and hypertension are increasing at an alarming rate worldwide. Current interventions seem ineffective to halt this p...
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Article
CNTF: a target therapeutic for obesity-related metabolic disease?
Obesity and type 2 diabetes are the most prevalent metabolic diseases in the western world. Alarmingly, the cluster of pathologies characteristic of obesity-induced disease have started to emerge in children, ...
