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  1. No Access

    Article

    Inhibition of Human Breast Cancer Cell Growth by Blockade of the Mevalonate-Protein Prenylation Pathway is not Prevented by Overexpression of Cyclin D1

    Overexpression of the cyclin D1 (CCND1) gene, encoding a downstream effector of mitogenic signals that plays a central role in G1 phase progression, is often found in cancerous cells. In sporadic breast cancer (B...

    Domenico Germano, Carmen Pacilio, Massimo Cancemi… in Breast Cancer Research and Treatment (2001)

  2. No Access

    Chapter and Conference Paper

    Transcriptional Control of Cell Cycle Progression by Estrogenic Hormones: Regulation of Human Cyclin D1 Gene Promoter Activity by Estrogen Receptor-a

    Estrogens (Es) are mitogens for breast and uterine epithelial cells, where they exert also a tumor-promoting action that appears to be directly linked to their growth promoting effects (1-3). Although during r...

    Valeria Belsito Petrizzi, Luigi Cicatiello, Lucia Altucci… in Hormonal Carcinogenesis III (2001)