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  1. Article

    Open Access

    Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

    Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergisticall...

    Yilun Sun, Simone A. Baechler, **aohu Zhang, Suresh Kumar… in Nature Communications (2023)

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  2. Article

    Open Access

    Consecutive entosis stages in human substrate-dependent cultured cells

    Entosis, or cell death by invading another cell, is typical for tumor epithelial cells. The formation of cell-in-cell structures is extensively studied in suspension cultures, but remains poorly understood in ...

    Anastasiia S. Garanina, Olga P. Kisurina-Evgenieva, Maria V. Erokhina… in Scientific Reports (2017)

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  3. No Access

    Chapter

    The MYC Network and Cancer

    Deregulation of c-Myc (referred to as MYC] contributes to the development of the most human tumors [1–3]. In addition to MYC, the Myc gene family contains three related genes, N-Myc, L-Myc, and S-Myc, which are a...

    Snorri S. Thorgeirsson, Valentina M. Factor in Signaling Pathways in Liver Diseases (2010)

  4. No Access

    Article

    Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice

    The micronutrient element selenium (Se) has been shown to be effective in reducing the incidence of cancer in animal models and human clinical trials. Selenoproteins and low molecular weight Se compounds were ...

    Sergey V Novoselov, Diego F Calvisi, Vyacheslav M Labunskyy, Valentina M Factor… in Oncogene (2005)

  5. No Access

    Article

    Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

    Deregulation of E2F transcriptional control has been implicated in oncogenic transformation. Consistent with this idea, we recently demonstrated that during hepatocarcinogenesis in c-myc/TGFα double transgenic mi...

    Elizabeth A Conner, Eric R Lemmer, Masako Omori, Peter J Wirth… in Oncogene (2000)