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Article
Open AccessLumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients
Anomalous aortic origin of the coronary artery (AAOCA) is a rare disease associated with sudden cardiac death, usually related to physical effort in young people. Clinical routine tests fail to assess the isch...
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Article
Open AccessDynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
Comprehensive genomic studies have delineated key driver mutations linked to disease progression for most cancers. However, corresponding transcriptional changes remain largely elusive because of the bias asso...
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Article
Open AccessDual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer
Driver genes with a mutually exclusive mutation pattern across tumor genomes are thought to have overlap** roles in tumorigenesis. In contrast, we show here that mutually exclusive prostate cancer driver alt...
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Article
Open AccessAngiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells
Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for advanced cell-based therapies. They are routinely obtained enzymatically from fat lipoaspirate (LP) as SVF, and may undergo prolonged e...
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Article
Open AccessDrug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model
Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therape...
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Article
Open AccessImmortalization of human adipose-derived stromal cells: production of cell lines with high growth rate, mesenchymal marker expression and capability to secrete high levels of angiogenic factors
Human adipose-derived stromal cells (hASCs), due to their relative feasibility of isolation and ability to secrete large amounts of angiogenic factors, are being evaluated for regenerative medicine. However, t...
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Article
Open AccessDecellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice
Silk fibroin (SF) scaffolds have been shown to be a suitable substrate for tissue engineering and to improve tissue regeneration when cellularized with mesenchymal stromal cells (MSCs). We here demonstrate, fo...
