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    Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

    Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the ...

    Masayuki Shimoda, Simona Principe, Hartland W. Jackson, Valbona Luga… in Nature Cell Biology (2014)